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本文引用的文献

1
Tau-targeting therapies for Alzheimer disease.针对阿尔茨海默病的 Tau 靶向治疗。
Nat Rev Neurol. 2018 Jul;14(7):399-415. doi: 10.1038/s41582-018-0013-z.
2
Prophylactic Active Tau Immunization Leads to Sustained Reduction in Both Tau and Amyloid-β Pathologies in 3xTg Mice.预防性主动 Tau 免疫可导致 3xTg 小鼠中 Tau 和淀粉样蛋白-β 病理持续减少。
Sci Rep. 2017 Dec 6;7(1):17034. doi: 10.1038/s41598-017-17313-1.
3
Preclinical and Clinical Development of ABBV-8E12, a Humanized Anti-Tau Antibody, for Treatment of Alzheimer's Disease and Other Tauopathies.ABBV-8E12，一种人源化抗 Tau 抗体的临床前和临床开发，用于治疗阿尔茨海默病和其他 Tau 病。
J Prev Alzheimers Dis. 2017;4(4):236-241. doi: 10.14283/jpad.2017.36.
4
Emerging Diagnostic and Therapeutic Strategies for Tauopathies.tau蛋白病的新兴诊断与治疗策略
Curr Neurol Neurosci Rep. 2017 Sep;17(9):72. doi: 10.1007/s11910-017-0779-1.
5
Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency.靶向病理性tau蛋白N端的人源化单克隆抗体armanezumab：特性与治疗效力
Mol Neurodegener. 2017 May 5;12(1):33. doi: 10.1186/s13024-017-0172-1.
6
Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy.给予抗tau抗体可增加转基因小鼠和tau蛋白病患者血浆中的tau蛋白水平。
Sci Transl Med. 2017 Apr 19;9(386). doi: 10.1126/scitranslmed.aal2029.
7
AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy.腺相关病毒介导的抗tau单链抗体片段表达可减少tau蛋白病小鼠模型中的tau蛋白积累。
J Exp Med. 2017 May 1;214(5):1227-1238. doi: 10.1084/jem.20162125. Epub 2017 Apr 17.
8
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.靶向病理性tau蛋白的抗体可阻断体外培养的神经元对tau蛋白的摄取及中间神经元对tau蛋白的传播。
Am J Pathol. 2017 Jun;187(6):1399-1412. doi: 10.1016/j.ajpath.2017.01.022. Epub 2017 Apr 11.
9
Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model.扫描超声与tau特异性单链抗体在tau转基因小鼠模型中的联合作用
Brain. 2017 May 1;140(5):1220-1230. doi: 10.1093/brain/awx052.
10
MultiTEP platform-based DNA epitope vaccine targeting N-terminus of tau induces strong immune responses and reduces tau pathology in THY-Tau22 mice.基于MultiTEP平台的靶向tau蛋白N端的DNA表位疫苗可诱导强烈的免疫反应并减轻THY-Tau22小鼠的tau病理变化。
Vaccine. 2017 Apr 11;35(16):2015-2024. doi: 10.1016/j.vaccine.2017.03.020. Epub 2017 Mar 18.

tau 免疫疗法治疗阿尔茨海默病和相关 tau 病：进展和潜在陷阱。

Tau Immunotherapies for Alzheimer's Disease and Related Tauopathies: Progress and Potential Pitfalls.

机构信息

Departments of Neuroscience and Physiology, and Psychiatry, Neuroscience Institute, New York University School of Medicine, New York, NY, USA.

出版信息

J Alzheimers Dis. 2018;64(s1):S555-S565. doi: 10.3233/JAD-179937.

DOI:10.3233/JAD-179937
PMID:29865056
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6171771/
Abstract

Tau immunotherapies have now advanced from proof-of-concept studies to Phase II clinical trials. This review briefly outlines developments in the field and discusses how these therapies may work, which involves multiple variables that are connected in complex ways. These various factors are likely to define therapeutic success in humans and have not been thoroughly investigated, at least based on published reports.

摘要

tau 免疫疗法现在已经从概念验证研究推进到了 II 期临床试验。本文简要概述了该领域的发展，并讨论了这些疗法的作用机制，其中涉及多个以复杂方式相互关联的变量。这些各种因素可能会定义 tau 免疫疗法在人类中的治疗成功，而且至少根据已发表的报告，这些因素尚未得到彻底研究。