阿替匹林C在一组人宫颈癌细胞系中诱导选择性氧化应激并抑制迁移和侵袭。
Artepillin C Induces Selective Oxidative Stress and Inhibits Migration and Invasion in a Comprehensive Panel of Human Cervical Cancer Cell Lines.
作者信息
Souza Raquel P, Bonfim-Mendonça Patrícia S, Damke Gabrielle M Z F, de-Assis Carvalho Analine R B, Ratti Bianca A, Dembogurski Djaceli S O, da-Silva Vânia R S, Silva Sueli O, Da-Silva Denise B, Bruschi Marcos L, Maria-Engler Silvya S, Consolaro Marcia E L
机构信息
Postgraduate Program in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana, Brazil.
Laboratory of Natural Products and Mass Spectrometry (LAPNEM), Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
出版信息
Anticancer Agents Med Chem. 2018;18(12):1750-1760. doi: 10.2174/1871520618666180604092930.
BACKGROUND
Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) is the main bioactive component of Brazilian green propolis, and possesses, among other things, anticancer properties. However, to the best of our knowledge, there are no studies of artepillin C in cervical cancer.
METHOD
To explore a new therapeutic candidate for cervical cancer, we have evaluated the effects of artepillin C on cellular viability in a comprehensive panel of human cervical cancer-derived cell lines including HeLa (human papillomavirus/HPV 18-positive), SiHa (HPV 16-positive), CaSki (HPV 16- and 18-positive) and C33A (HPV-negative) cells compared to a spontaneously immortalized human epithelial cell line (HaCaT).
RESULTS
Our results demonstrated that artepillin C had a selective effect on cellular viability and could induce apoptosis possibly by intrinsic pathway, likely a result of oxidative stress, in all cancer-derived cell lines but not in HaCaT. Additionally, artepillin C was able to inhibit the migration and invasion of cancer cells.
CONCLUSION
Thus, artepillin C appears to be a promising new candidate as an anticancer drug for cervical cancer induced by different HPV types.
背景
阿替匹林C（3,5-二异戊烯基-4-羟基肉桂酸）是巴西绿蜂胶的主要生物活性成分，具有抗癌特性等。然而，据我们所知，尚无关于阿替匹林C在宫颈癌方面的研究。
方法
为探索宫颈癌的新治疗候选药物，我们评估了阿替匹林C对一系列人宫颈癌衍生细胞系（包括HeLa（人乳头瘤病毒/HPV 18阳性）、SiHa（HPV 16阳性）、CaSki（HPV 16和18阳性）和C33A（HPV阴性）细胞）以及自发永生化人上皮细胞系（HaCaT）细胞活力的影响。
结果
我们的结果表明，阿替匹林C对细胞活力有选择性作用，并且可能通过内源性途径诱导所有癌症衍生细胞系凋亡，这可能是氧化应激的结果，但对HaCaT细胞无此作用。此外，阿替匹林C能够抑制癌细胞的迁移和侵袭。
结论
因此，阿替匹林C似乎是一种有前景的新型抗癌药物候选物，可用于治疗由不同HPV类型诱导的宫颈癌。
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