Kumar Lalit, Baldi Ashish, Verma Shivani, Utreja Puneet
Faculty of Pharmaceutical Sciences, Department of Pharmaceutics, PCTE Group of Institutes, Ludhiana, Punjab 142021, India.
I.K. Gujral Punjab Technical University, Jalandhar-Punjab 144601, India.
Pharm Nanotechnol. 2018;6(2):94-110. doi: 10.2174/2211738506666180604101920.
Breast cancer is the most widely occurring non-cutaneous cancer in women. Treatment options available for breast cancer are limited and there are a number of toxicity concerns associated with them. Therefore, nanocarrier based approaches have been explored for breast cancer treatment. Nanocarriers implemented for breast cancer treatment are nanoliposomes, polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, gold nanoparticles, dendrimers, and protein nanocages.
Objective of this review was to explore the therapeutic efficacy of various nanocarrier systems against breast cancer.
Existing literature regarding nanocarrier systems for breast cancer therapy was reviewed using Pubmed and Google Scholar.
Nanocarriers may show prolonged circulation time of chemotherapeutic agent with efficient breast tumor targeting. Both active and passive targeting methodologies can be explored to target breast cancer cells using different nanocarriers. Targeted nanocarriers have the capability to reduce side effects caused by various conventional formulations used to treat breast cancer.
Various nanocarriers listed above have shown their therapeutic potential in preclinical studies to treat breast cancer. Satisfactory clinical evaluation and scale up techniques can promote their entry into the pharmaceutical market in greater extent.
乳腺癌是女性中最常见的非皮肤癌。乳腺癌的现有治疗选择有限，并且存在许多与之相关的毒性问题。因此，已探索基于纳米载体的方法来治疗乳腺癌。用于乳腺癌治疗的纳米载体包括纳米脂质体、聚合物纳米颗粒、固体脂质纳米颗粒、纳米结构脂质载体、金纳米颗粒、树枝状大分子和蛋白质纳米笼。
本综述的目的是探讨各种纳米载体系统对乳腺癌的治疗效果。
使用PubMed和谷歌学术对有关用于乳腺癌治疗的纳米载体系统的现有文献进行综述。
纳米载体可能会使化疗药物的循环时间延长，并有效靶向乳腺肿瘤。可以探索主动和被动靶向方法，使用不同的纳米载体靶向乳腺癌细胞。靶向纳米载体有能力减少用于治疗乳腺癌的各种传统制剂所引起的副作用。
上述各种纳米载体在治疗乳腺癌的临床前研究中已显示出其治疗潜力。令人满意的临床评估和放大技术可以在更大程度上促进它们进入制药市场。
