Talluri Siddartha Venkata, Kuppusamy Gowthamarajan, Karri Veera Venkata Satyanarayana Reddy, Tummala Shashank, Madhunapantula SubbaRao V
a Department of Pharmaceutics , JSS College of Pharmacy, JSS University , Udhagamandalam , Tamil Nadu , India and.
b Department of Biochemistry , JSS Medical College, JSS University , Mysore , Karnataka , India.
Drug Deliv. 2016 May;23(4):1291-305. doi: 10.3109/10717544.2015.1092183. Epub 2015 Oct 2.
Breast cancer is the second leading cancer-related disease as the most common non-cutaneous malignancy among women. Curative options for breast cancer are limited, therapeutically substantial and associated with toxicities. Emerging nanotechnologies exhibited the possibility to treat or target breast cancer. Among the nanoparticles, various lipid nanoparticles namely, liposomes, solid lipid nanoparticles, nanostructured lipid carriers and lipid polymer hybrid nanoparticles have been developed over the years for the breast cancer therapy and evidences are documented. Concepts are confined in lab scale, which needs to be transferred to large scale to develop active targeting nanomedicine for the clinical utility. So, the present review highlights the recently published studies in the development of lipid-based nanocarriers for breast cancer treatment.
乳腺癌是女性中最常见的非皮肤恶性肿瘤，是第二大致癌相关疾病。乳腺癌的治愈选择有限，治疗难度大且伴有毒性。新兴的纳米技术显示出治疗或靶向乳腺癌的可能性。多年来，在纳米颗粒中，已开发出各种脂质纳米颗粒，即脂质体、固体脂质纳米颗粒、纳米结构脂质载体和脂质聚合物杂化纳米颗粒用于乳腺癌治疗，且有相关证据记录在案。相关概念目前局限于实验室规模，需要扩大规模以开发用于临床应用的主动靶向纳米药物。因此，本综述重点介绍了最近发表的关于开发用于乳腺癌治疗的脂质基纳米载体的研究。
