Department of Clinical Laboratory, the First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
BMC Cancer. 2019 Apr 4;19(1):314. doi: 10.1186/s12885-019-5504-9.
Mean platelet volume (MPV) is a marker of platelet activation. MPV and platelet count (PC) are negatively correlated, and their ratio (MPV/PC) is informative for the diagnosis of malignant tumors. However, the relationship between MPV/PC and colorectal cancer is unclear. This retrospective clinical study aimed to evaluate the diagnostic value of MPV/PC in colorectal cancer.
Hematological examinations were performed at initial diagnosis in patients with colorectal cancer (n = 186) or adenomatous polyp (n = 132) and healthy controls (n = 108). Hematological parameters evaluated included white blood cells, red blood cells, hemoglobin, neutrophils, lymphocytes, monocytes, PC, and MPV. Statistical analyses included Student's t-test, one-way ANOVA or Kruskal-Wallis H test, chi-square tests, Spearman's correlation test and receiver operating characteristic (ROC). ROC curve was used to evaluate the diagnostic values of MPV and MPV/PC in colorectal cancer.
Among these groups, MPV was significantly lower in colorectal cancer than in adenomatous polyp (p = 0.002) and healthy controls (p < 0.001) but did not significantly differ between adenomatous polyp and healthy controls (p = 0.210). MPV/PC was lower in colorectal cancer compared with adenomatous polyp and healthy controls (p < 0.001) and in adenomatous polyp compared with healthy controls (p = 0.010). MPV did not significantly differ among colorectal cancer subgroups, while MPV/PC significantly differed between TNM stages and the presence/absence of lymph node metastasis. MPV/PC was negatively correlated with the neutrophil to lymphocyte ratio(NLR) (p = 0.002) and platelet to lymphocyte ratio(PLR) concentration (p < 0.001). In the differential diagnosis between colorectal cancer and adenomatous polyp, MPV/PC produced a larger ROC curve than MPV, NLR or PLR alone. Using MPV/PC to distinguish between colorectal cancer and controls produced a larger AUC than using MPV or NLR alone.
MPV/PC may be useful for the diagnosis of colorectal cancer. However, further studies are warranted to include additional regions and more data, to assess the utility of MPV/PC as a novel diagnostic screening tool for colorectal cancer.
平均血小板体积（MPV）是血小板活化的标志物。MPV 与血小板计数（PC）呈负相关，其比值（MPV/PC）对恶性肿瘤的诊断具有提示作用。然而，MPV/PC 与结直肠癌的关系尚不清楚。本回顾性临床研究旨在评估 MPV/PC 在结直肠癌中的诊断价值。
对 186 例结直肠癌患者、132 例腺瘤性息肉患者和 108 例健康对照者的初诊时进行血液学检查。评估的血液学参数包括白细胞、红细胞、血红蛋白、中性粒细胞、淋巴细胞、单核细胞、PC 和 MPV。统计分析包括 Student's t 检验、单因素方差分析或 Kruskal-Wallis H 检验、卡方检验、Spearman 相关检验和受试者工作特征（ROC）曲线。ROC 曲线用于评估 MPV 和 MPV/PC 在结直肠癌中的诊断价值。
与腺瘤性息肉和健康对照组相比，结直肠癌患者的 MPV 明显降低（p=0.002 和 p<0.001），但与腺瘤性息肉患者之间无显著差异（p=0.210）。与腺瘤性息肉和健康对照组相比，结直肠癌患者的 MPV/PC 明显降低（p<0.001），与腺瘤性息肉患者相比，结直肠癌患者的 MPV/PC 也明显降低（p=0.010）。结直肠癌各亚组之间的 MPV 无显著差异，而 MPV/PC 在 TNM 分期和有无淋巴结转移之间存在显著差异。MPV/PC 与中性粒细胞与淋巴细胞比值（NLR）呈负相关（p=0.002），与血小板与淋巴细胞比值（PLR）浓度呈负相关（p<0.001）。在结直肠癌与腺瘤性息肉的鉴别诊断中，MPV/PC 产生的 ROC 曲线大于 MPV、NLR 或 PLR 单独产生的 ROC 曲线。使用 MPV/PC 区分结直肠癌与对照组的 AUC 大于单独使用 MPV 或 NLR。
MPV/PC 可能有助于结直肠癌的诊断。然而，需要进一步的研究来纳入更多的地区和数据，以评估 MPV/PC 作为结直肠癌新型诊断筛查工具的效用。
