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Maedica (Bucur). 2018 Mar;13(1):55-60.
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Community-acquired necrotizing pneumonia caused by methicillin-resistant Staphylococcus aureus producing Panton-Valentine leukocidin in a Chinese teenager: case report and literature review.中国青少年耐甲氧西林金黄色葡萄球菌产 Panton-Valentine 白细胞素引起的社区获得性坏死性肺炎:病例报告及文献复习。
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本文引用的文献

1
Necrotizing pneumonia: an emerging problem in children?坏死性肺炎:儿童中一个新出现的问题?
Pneumonia (Nathan). 2017 Jul 25;9:11. doi: 10.1186/s41479-017-0035-0. eCollection 2017.
2
Management of necrotizing pneumonia and pulmonary gangrene: a case series and review of the literature.坏死性肺炎和肺坏疽的管理:病例系列及文献综述
Can Respir J. 2014 Jul-Aug;21(4):239-45. doi: 10.1155/2014/864159. Epub 2014 May 2.
3
Necrotizing pneumonia in children: report of 41 cases between 2006 and 2011 in a French tertiary care center.儿童坏死性肺炎:2006 年至 2011 年法国一家三级保健中心的 41 例报告。
Pediatr Infect Dis J. 2013 Oct;32(10):1146-9. doi: 10.1097/INF.0b013e31829be1bb.
4
Necrotizing pneumonia: a rare complication of pneumonia requiring special consideration.坏死性肺炎:肺炎的罕见并发症,需特别考虑。
Curr Opin Pulm Med. 2012 May;18(3):246-52. doi: 10.1097/MCP.0b013e3283521022.
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Necrotising pneumonia is an increasingly detected complication of pneumonia in children.坏死性肺炎是一种在儿童中越来越多地被检测到的肺炎并发症。
Eur Respir J. 2008 Jun;31(6):1285-91. doi: 10.1183/09031936.00099807. Epub 2008 Jan 23.
6
Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia.金黄色葡萄球菌杀白细胞素可导致坏死性肺炎。
Science. 2007 Feb 23;315(5815):1130-3. doi: 10.1126/science.1137165. Epub 2007 Jan 18.
7
Necrotizing pneumococcal pneumonia in children: the role of pulmonary gangrene.儿童坏死性肺炎球菌肺炎:肺坏疽的作用
Pediatr Pulmonol. 2006 Jul;41(7):623-9. doi: 10.1002/ppul.20411.
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Necrotizing pneumonia in children.
Acta Paediatr. 2004 Sep;93(9):1172-7. doi: 10.1080/08035250410026699.
9
Clinical manifestations and molecular epidemiology of necrotizing pneumonia and empyema caused by Streptococcus pneumoniae in children in Taiwan.台湾地区儿童肺炎链球菌所致坏死性肺炎及脓胸的临床表现与分子流行病学
Clin Infect Dis. 2004 Mar 15;38(6):830-5. doi: 10.1086/381974. Epub 2004 Feb 27.
10
Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients.携带杀白细胞素基因的金黄色葡萄球菌菌株与年轻免疫功能正常患者的高致死性坏死性肺炎之间的关联。
Lancet. 2002 Mar 2;359(9308):753-9. doi: 10.1016/S0140-6736(02)07877-7.

儿童重症肺炎一例的进化特殊性——病例报告

Evolutionary Particularities in a Case of Severe Pneumonia in Children - Case Report.

作者信息

Ionescu Marcela Daniela, Popescu Nicoleta Aurelia, Balan Georgiana, Marcu Veronica, Enculescu Augustina, Vatra Lorena, Oancea Marcel, Balgradean Mihaela

机构信息

1st Pediatric Department, "MS Curie" Emergency Children's Hospital, Bucharest, Romania.

Radiology Department, "MS Curie" Emergency Children's Hospital, Bucharest, Romania.

出版信息

Maedica (Bucur). 2018 Mar;13(1):55-60.

PMID:29868142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5972790/
Abstract

Necrotizing pneumonia remains an uncommon complication of pneumonia in children, but its incidence is increasing. Pneumococcal infection is the predominant cause of severe necrotizing pneumonia in children, but methicillin resistant Staphylococcus aureus (MRSA) and Panton-Valentine leukocidin (PVL) staphylococcal infections are also important. We present the case of a four-year-old girl,with an unremarkable medical history, who was admitted in our hospital with a history of high fever, productive cough and tachypnea lasting for 10 days, progressive worsening despite empirical oral antibiotic. Following physical examination, laboratory investigations and thoracic radiography, we established the diagnosis of left lower lobe pneumonia with parapneumonic effusion, acute respiratory failure and sepsis. Medical treatment with systemic antibiotics was initiated, but the evolution was unfavorable. Seriated chest X-rays and also high resolution computed tomography with contrast of the lung were performed, revealing the progression to extensive necrotizing pneumonia with multiple cystic lesions causing right mediastinal deflection. The parenteral broad spectrum antibiotic regimen was adjusted, still with unfavorable evolution, requiring surgical treatment (left inferior lobectomy and pleural draining). Postoperatively, recovery was uneventful. The patient was discharged with clinical and laboratory improvement of his condition, a repeated chest X-ray showing good expansion of upper left parenchyma.

摘要

坏死性肺炎仍是儿童肺炎中一种不常见的并发症,但其发病率正在上升。肺炎球菌感染是儿童重症坏死性肺炎的主要病因,但耐甲氧西林金黄色葡萄球菌(MRSA)和杀白细胞素(PVL)葡萄球菌感染也很重要。我们报告一例4岁女童病例,其既往病史无特殊,因高热、咳痰及呼吸急促持续10天入院,尽管接受了经验性口服抗生素治疗,病情仍逐渐加重。经过体格检查、实验室检查及胸部X线检查,我们确诊为左下叶肺炎伴胸腔积液、急性呼吸衰竭及脓毒症。开始采用全身性抗生素进行药物治疗,但病情进展不利。进行了系列胸部X线检查以及肺部增强高分辨率计算机断层扫描,结果显示病情进展为广泛性坏死性肺炎,伴有多个囊性病变,导致右纵隔移位。调整了肠外广谱抗生素治疗方案,但病情仍无好转,需要进行手术治疗(左下叶切除术及胸腔引流)。术后恢复顺利。患者出院时临床症状及实验室检查结果均有改善,复查胸部X线显示左上肺实质良好扩张。