Ionescu Marcela Daniela, Popescu Nicoleta Aurelia, Balan Georgiana, Marcu Veronica, Enculescu Augustina, Vatra Lorena, Oancea Marcel, Balgradean Mihaela
1st Pediatric Department, "MS Curie" Emergency Children's Hospital, Bucharest, Romania.
Radiology Department, "MS Curie" Emergency Children's Hospital, Bucharest, Romania.
Maedica (Bucur). 2018 Mar;13(1):55-60.
Necrotizing pneumonia remains an uncommon complication of pneumonia in children, but its incidence is increasing. Pneumococcal infection is the predominant cause of severe necrotizing pneumonia in children, but methicillin resistant Staphylococcus aureus (MRSA) and Panton-Valentine leukocidin (PVL) staphylococcal infections are also important. We present the case of a four-year-old girl,with an unremarkable medical history, who was admitted in our hospital with a history of high fever, productive cough and tachypnea lasting for 10 days, progressive worsening despite empirical oral antibiotic. Following physical examination, laboratory investigations and thoracic radiography, we established the diagnosis of left lower lobe pneumonia with parapneumonic effusion, acute respiratory failure and sepsis. Medical treatment with systemic antibiotics was initiated, but the evolution was unfavorable. Seriated chest X-rays and also high resolution computed tomography with contrast of the lung were performed, revealing the progression to extensive necrotizing pneumonia with multiple cystic lesions causing right mediastinal deflection. The parenteral broad spectrum antibiotic regimen was adjusted, still with unfavorable evolution, requiring surgical treatment (left inferior lobectomy and pleural draining). Postoperatively, recovery was uneventful. The patient was discharged with clinical and laboratory improvement of his condition, a repeated chest X-ray showing good expansion of upper left parenchyma.
坏死性肺炎仍是儿童肺炎中一种不常见的并发症,但其发病率正在上升。肺炎球菌感染是儿童重症坏死性肺炎的主要病因,但耐甲氧西林金黄色葡萄球菌(MRSA)和杀白细胞素(PVL)葡萄球菌感染也很重要。我们报告一例4岁女童病例,其既往病史无特殊,因高热、咳痰及呼吸急促持续10天入院,尽管接受了经验性口服抗生素治疗,病情仍逐渐加重。经过体格检查、实验室检查及胸部X线检查,我们确诊为左下叶肺炎伴胸腔积液、急性呼吸衰竭及脓毒症。开始采用全身性抗生素进行药物治疗,但病情进展不利。进行了系列胸部X线检查以及肺部增强高分辨率计算机断层扫描,结果显示病情进展为广泛性坏死性肺炎,伴有多个囊性病变,导致右纵隔移位。调整了肠外广谱抗生素治疗方案,但病情仍无好转,需要进行手术治疗(左下叶切除术及胸腔引流)。术后恢复顺利。患者出院时临床症状及实验室检查结果均有改善,复查胸部X线显示左上肺实质良好扩张。