Departamento de Fisiología, Facultad de Medicina, México City, México.
Instituto de Fisiología Celular, México City, México.
Elife. 2018 Jun 5;7:e36372. doi: 10.7554/eLife.36372.
Temperature-activated TRP channels or thermoTRPs are among the only proteins that can directly convert temperature changes into changes in channel open probability. In spite of a wealth of functional and structural information, the mechanism of temperature activation remains unknown. We have carefully characterized the repeated activation of TRPV1 by thermal stimuli and discovered a previously unknown inactivation process, which is irreversible. We propose that this form of gating in TRPV1 channels is a consequence of the heat absorption process that leads to channel opening.
温度激活型瞬时受体电位通道（TRP 通道）或热 TRP 通道是唯一能将温度变化直接转化为通道开放概率变化的蛋白之一。尽管已经有了丰富的功能和结构信息，但温度激活的机制仍不清楚。我们仔细研究了 TRPV1 受温度刺激的重复激活，并发现了一种以前未知的不可逆失活过程。我们提出，这种 TRPV1 通道的门控形式是导致通道开放的热吸收过程的结果。
