中国儿童中FTO基因rs6499640多态性与血脂水平的性别特异性关联
Gender-specific association of the rs6499640 polymorphism in the FTO gene with plasma lipid levels in Chinese children.
作者信息
Gao Liwang, Wu Lijun, Zhang Meixian, Zhao Xiaoyuan, Cheng Hong, Mi Jie
机构信息
Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
出版信息
Genet Mol Biol. 2018;41(2):397-402. doi: 10.1590/1678-4685-GMB-2017-0107. Epub 2018 Jun 4.
The fat mass- and obesity-associated gene (FTO) is significantly associated with obesity, but the associations of FTO with obesity-related traits are not fully described. We aimed to investigate the association of the FTO single nucleotide polymorphism (SNP) rs6499640 with lipid levels in Chinese children. A total of 3503 children aged 6-18 years were included in the present study. Lipid levels were analyzed and the SNP rs6499640 was genotyped using the TaqMan Allelic Discrimination Assay. Statistically significant associations were found between rs6499640 and low-density lipoprotein cholesterol (LDL-C) (p = 0.008), total cholesterol (TC) (p = 0.005), and triglycerides (TG) (p < 0.001) in girls under a dominant model adjusted for age and BMI. No statistical significance was found between the SNP and lipid levels in boys. We demonstrated for the first time that the SNP rs6499640 in FTO is associated with LDL-C, TC, and TG in Chinese girls. Our study identified a new risk locus for lipid levels in children.
脂肪量和肥胖相关基因（FTO）与肥胖显著相关，但FTO与肥胖相关性状之间的关联尚未完全阐明。我们旨在研究FTO单核苷酸多态性（SNP）rs6499640与中国儿童血脂水平的关联。本研究共纳入3503名6至18岁的儿童。分析血脂水平，并使用TaqMan等位基因鉴别分析对SNP rs6499640进行基因分型。在年龄和BMI校正的显性模型下，发现rs6499640与女孩的低密度脂蛋白胆固醇（LDL-C）（p = 0.008）、总胆固醇（TC）（p = 0.005）和甘油三酯（TG）（p < 0.001）之间存在统计学显著关联。该SNP与男孩血脂水平之间未发现统计学显著性。我们首次证明FTO中的SNP rs6499640与中国女孩的LDL-C、TC和TG相关。我们的研究确定了儿童血脂水平的一个新风险位点。
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