Kolozsvári László Róbert, Kovács Zoltán György, Szőllősi Gergő József, Harsányi Szilvia, Frecska Ede, Égerházi Anikó
Department of Family and Occupational Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.
Department of Psychiatry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Ideggyogy Sz. 2017 Jul 30;70(7-8):267-272. doi: 10.18071/isz.70.0267.
Concerns regarding the projected prevalence of Alzheimer's disease (AD) over the next several decades have stimulated a need for the detection of AD in its earliest stages. A self-administered cognitive test (Test Your Memory, TYM) is designed as a short, cognitive screening tool for the detection of AD. Our aim was to validate the Hungarian version of the Test Your Memory (TYM-HUN) test for the detection of AD. The TYM-HUN was applied in case of individuals aged 60 years or more, 50 patients with AD and 50 healthy controls were recruited into the study. We compared the diagnostic utility of the Hungarian version of the TYM in AD with that of the Mini-Mental State Examination (MMSE). The sensitivity and specificity of the TYM-HUN in the detection of Alzheimer's disease were determined. The patients with AD scored an average of 15.5/30 on the MMSE and 20.3/50 on the TYM-HUN. The average score achieved by the members of the healthy control group was 27.3/30 on the MMSE and 42.7/50 on the TYM. The total TYM-HUN scores significantly correlated with the MMSE scores (Spearman's rho, r=0.8830; p<0.001). Multivariate logistic regression model demonstrated that a one-point increase in the TYM score reduced the probability of having AD by 36%. The optimal cut-off score on the TYM-HUN was 35/36 along with 94% sensitivity and 94% specificity for the detection of AD. The TYM has a much wider scoring range than the MMSE and is also a suitable screening tool for memory problems, furthermore, it fulfils the requirements of being a short cognitive test for the non-specialists. The TYM-HUN is useful for the detection of Alzheimer's disease and can be applied as a screening test in Hungarian memory clinics as well as in primary care settings.
对未来几十年阿尔茨海默病（AD）预计患病率的担忧激发了在其最早阶段检测AD的需求。一种自我管理的认知测试（测试你的记忆力，TYM）被设计为一种用于检测AD的简短认知筛查工具。我们的目的是验证匈牙利版的测试你的记忆力（TYM-HUN）测试用于检测AD的有效性。TYM-HUN应用于60岁及以上的个体，招募了50名AD患者和50名健康对照者参与研究。我们将匈牙利版TYM在AD中的诊断效用与简易精神状态检查表（MMSE）进行了比较。确定了TYM-HUN在检测阿尔茨海默病中的敏感性和特异性。AD患者在MMSE上的平均得分为15.5/30，在TYM-HUN上的平均得分为20.3/50。健康对照组成员在MMSE上的平均得分为27.3/30，在TYM上的平均得分为42.7/50。TYM-HUN的总得分与MMSE得分显著相关（斯皮尔曼相关系数，r = 0.8830；p < 0.001）。多变量逻辑回归模型表明，TYM得分每增加一分，患AD的概率降低36%。TYM-HUN的最佳截断分数为35/36，检测AD的敏感性为94%，特异性为94%。TYM的评分范围比MMSE宽得多，也是一种适用于记忆问题的筛查工具，此外，它满足了作为非专业人员简短认知测试的要求。TYM-HUN可用于检测阿尔茨海默病，可作为匈牙利记忆诊所以及初级保健机构中的筛查测试。
