Barulli Maria Rosaria, Piccininni Marco, Brugnolo Andrea, Musarò Cinzia, Di Dio Cristina, Capozzo Rosa, Tortelli Rosanna, Lucca Ugo, Logroscino Giancarlo
Department of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari "Aldo Moro", "Pia Fondazione Cardinale G. Panico", Tricase, Italy.
Institute of Public Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Front Psychol. 2021 Jan 18;11:614920. doi: 10.3389/fpsyg.2020.614920. eCollection 2020.
The Test Your Memory (TYM) is a brief self-administered, cognitive screening test, currently used in several settings. It requires minimal administrator supervision and the computation of the final test score takes approximately 2 min. We assessed the discrimination ability of the Italian version of the TYM (TYM-I) in detecting Mild Cognitive Impairment (MCI) in clinical setting. TYM-I was administered to 94 MCI patients and 134 healthy controls. The clinical diagnosis of MCI was considered as the gold standard. An extended formal neuropsychological test battery was used to define MCI subtypes. Receiver Operating Characteristic (ROC) analyses were conducted to find the optimal cut-off and measure discrimination ability of TYM-I in detecting MCI. TYM-I had a similar area under the curve (AUC = 0.85) point estimate as Mini Mental State Examination (MMSE) (AUC = 0.83). A TYM-I score lower or equal to 36 was found to be optimal cut off to detect MCI. The TYM-I showed the highest discrimination ability among individuals aged more than 70 and high educational level (AUC = 0.89). The amnestic MCI subtype patients, compared to non-amnestic MCI patients, had worse performance in recall, orientation and visuospatial abilities TYM-I subscores. The TYM-I is a valid screening test in detecting cognitive dysfunction, easily carried out in clinical practice. The TYM-I subscores may allow to identify amnestic and non-amnestic MCI subtypes.
“测试你的记忆力”（TYM）是一种简短的自我管理认知筛查测试，目前在多个场景中使用。它需要最少的管理员监督，最终测试分数的计算大约需要2分钟。我们评估了意大利版TYM（TYM-I）在临床环境中检测轻度认知障碍（MCI）的辨别能力。对94名MCI患者和134名健康对照者进行了TYM-I测试。MCI的临床诊断被视为金标准。使用扩展的正式神经心理学测试组合来定义MCI亚型。进行了受试者操作特征（ROC）分析，以找到最佳临界值并测量TYM-I在检测MCI方面的辨别能力。TYM-I的曲线下面积（AUC = 0.85）点估计与简易精神状态检查表（MMSE）（AUC = 0.83）相似。发现TYM-I分数低于或等于36是检测MCI的最佳临界值。TYM-I在70岁以上且教育水平高的个体中显示出最高的辨别能力（AUC = 0.89）。与非遗忘型MCI患者相比，遗忘型MCI亚型患者在回忆、定向和视觉空间能力TYM-I子分数方面表现更差。TYM-I是一种检测认知功能障碍的有效筛查测试，可在临床实践中轻松进行。TYM-I子分数可能有助于识别遗忘型和非遗忘型MCI亚型。
