Eckstein R P, Russell P, Friedlander M L, Tattersall M H, Bradfield A
Hum Pathol. 1985 Jun;16(6):632-6. doi: 10.1016/s0046-8177(85)80114-3.
The clinicopathologic features of placental site trophoblastic tumor (PSTT), a rare form of trophoblastic disease, were systematically described only relatively recently. Previously, in endometrial curettage and hysterectomy specimens, PSTT was not distinguished from choriocarcinoma or sarcoma, although in most cases the natural history had been benign. A case of biopsy-proved metastasis to para-aortic lymph nodes with radiologic evidence of lung metastasis is reported. Histologically, the tumor appeared similar to the tumors in other reported cases of PSTT. The mitotic rate was variable, being very high in a few small fragments obtained by curettage. Flow cytometric analysis of the tumor showed cells with diploid DNA content and a relatively low proliferative fraction. The tumor maintained its morphologic and functional characteristics following xenotransplantation into Balb/c nu/nu mice. In spite of a treatment regimen that included hysterectomy and multiagent chemotherapy, the patient continued to have evidence of persistent trophoblastic disease 15 months after presentation.
胎盘部位滋养细胞肿瘤（PSTT）是一种罕见的滋养细胞疾病，其临床病理特征直到最近才得到系统描述。此前，在子宫内膜刮宫和子宫切除标本中，PSTT未与绒毛膜癌或肉瘤区分开来，尽管在大多数情况下其自然病程是良性的。本文报告了一例经活检证实转移至主动脉旁淋巴结且有肺部转移影像学证据的病例。组织学上，该肿瘤与其他报道的PSTT病例中的肿瘤相似。有丝分裂率各不相同，在刮宫获取的一些小组织碎片中非常高。对该肿瘤的流式细胞术分析显示细胞DNA含量为二倍体，增殖分数相对较低。将该肿瘤异种移植到Balb/c nu/nu小鼠体内后，其形态和功能特征得以保留。尽管采用了包括子宫切除和多药化疗的治疗方案，但该患者在就诊15个月后仍有持续性滋养细胞疾病的证据。
