[Efficacy of sublingual immunotherapy with Dermatophagoides farina drops in monosensitized and polysensitized children with allergic rhinitis and asthma].

To evaluate the efficacy of SLIT with Dermatophagoides farina drops in monosensitized and polysensitized children with allergic rhinitis and asthma.This retrospective analysis chose 124 cases of allergic rhinitis and asthma with 3 years SLIT treatment. According to skin prick test,they were divided into two groups, monosensitized group (48 patients) and polysensitized group (76 patients). Before SLIT and after SLIT for 1 year, 2 year and 3 years, the TNSS, TRMS of rhinitis and DASS, NASS, TAMS, VAS, PEF, FEV1 of asthma were evaluated. The TNSS, TRMS, DASS, NASS, TAMS, VAS, PEF, FEV1 had continuously improved significantly after SLIT for 1 year, 2 year and 3 years in two groups as compared with baseline (< 0.05). As compared with after SLIT for 1 year, after SLIT for 2 year the TNSS, TRMS, TAMS, VAS of monosensitized group had obviously decrease (= 3.76, 5.57, 6.02, 5.62, < 0.05). As compared with after SLIT for 1 year, similarly, after SLIT for 2 year the TNSS, TRMS, TAMS, VAS of polysensitized group had obviously decrease (= 5.40, 7.16, 7.19, 7.87, < 0.05). Before SLIT, TRMS and TAMS of polysensitized group were significantly greater than the monosensitized group (=3.16, 2.74, < 0.05). After SLIT for 1 year, 2 years and 3 years, the all evaluation indicators of two groups were not statistically significant (> 0.05).Sublingual immunotherapy with Dermatophagoides farina drops in monosensitized and polysensitized children with allergic rhinitis and asthma had similar and significant therapeutic effect.