Chen Bo-Ya, Long Zi-Ming, Huang Yan-Jun, Zeng Jian-Ming
Department of Otorhinolaryngology, Sanjii Hospital of Dongguan, Dongguan, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Jul;48(7):549-54.
To compare the efficacy of sublingual immunotherapy (SLIT) with standardized Dermatophagoides farinae drops in monosensitized and polysensitized patients with allergic rhinitis.
The efficacy of SLIT in 69 patients who were sensitized to house dust mites and treated with Dermatophagoides farinae drops for 1.5-2.0 year with complete clinical data were analyzed retrospectively. These patients had been divided into the monoallergen sensitized group and polyallergen sensitized group according to the results of skin prick tests. The total medication score (TMS) and the total nasal symptoms score (TNSS) were evaluated before and half an year, 1.0 year and 1.5-2.0 years after SLIT treatment.
After SLIT treatment for half an year, the TNSS in the monoallergen sensitized group (2.00 [1.00; 3.00]) was significantly lower than that in the polyallergen sensitized group (3.00 [2.00; 4.00], Z = -2.851, P < 0.05), this significant difference of TNSS between the two groups was also found after SLIT treatment for 1.0 year (0.00 [0.00; 1.00], 2.00 [0.00; 3.00], Z = -2.590, P < 0.05). Whereas, there was no significant difference between the two groups after 1.5-2.0 years treatment refer to the TNSS (0.00 [0.00; 1.00], 0.00 [0. 00; 2.00], Z = -1.461, P > 0.05). Half an year, 1.0 year and 1.5-2.0 years after SLIT treatment, the TMS in both groups reduced significantly, with no significant difference between two groups (Z value was - 0.777, -0.944, -0.907, all P > 0. 05).
SLIT with Dermatophagoides farinae drops is effective in monosensitized and polysensitized patients with allergic rhinitis. And equivalent efficacy could be achieved after 1.5-2.years.
比较舌下免疫疗法（SLIT）与标准化粉尘螨滴剂在单致敏和多致敏变应性鼻炎患者中的疗效。
回顾性分析69例对屋尘螨致敏并接受粉尘螨滴剂治疗1.5 - 2.0年且有完整临床资料患者的SLIT疗效。根据皮肤点刺试验结果将这些患者分为单过敏原致敏组和多过敏原致敏组。在SLIT治疗前、治疗半年后、1.0年后以及1.5 - 2.0年后评估总用药评分（TMS）和总鼻症状评分（TNSS）。
SLIT治疗半年后，单过敏原致敏组的TNSS（2.00[1.00；3.00]）显著低于多过敏原致敏组（3.00[2.00；4.00]，Z = -2.851，P < 0.05），SLIT治疗1.0年后两组间TNSS也存在显著差异（0.00[0.00；1.00]，2.00[0.00；3.00]，Z = -2.590，P < 0.05）。然而，治疗1.5 - 2.0年后两组间TNSS无显著差异（0.00[0.00；1.00]，0.00[0.00；2.00]，Z = -1.461，P > 0.05）。SLIT治疗半年后、1.0年后以及1.5 - 2.0年后，两组的TMS均显著降低，两组间无显著差异（Z值分别为 - 0.777、 - 0.944、 - 0.907，均P > 0.05）。
粉尘螨滴剂舌下免疫疗法对单致敏和多致敏变应性鼻炎患者有效，且在1.5 - 2.0年后可达到同等疗效。
