Chen Y H, Wang P F, Wang H J, Hu X, Li Z Y, Xiong H Q
Department of Respiratory Medicine, Dazhou Central Hospital, Dazhou, 635000, Chin.
Department of Otolaryngology Head and Neck Surgery, Dazhou Central Hospital.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Feb 20;31(4):301-304. doi: 10.13201/j.issn.1001-1781.2017.04.013.
To investigate the detection and significance of T cell CD69 expression in peripheral blood of patients with obstructive sleep apnea hypopnea syndrome (OSAHS).According to AHI, 81 OSAHS patients diagnosed by PSG were divided into 3 groups: light, medium and heavy, with 27 cases in each group; 27 patients without OSAHS as control group. Flow cytometry was used to detect the expression rate of CD69 in T cells, to analyze the correlation between the expression rate of CD69 on T cells and the gender, age, BMI, and PSG index.①The CD69 expression rate of T cells in peripheral blood of OSAHS patients with snoring degree increases gradually (< 0.05); Comparison between the two shows that there was no significant difference in CD69 expression rate on T cells between the control group and the mild group (= 1.649, > 0.05); there were significant differences between the other groups (< 0.05). ②The CD69 expression rate of T cells in peripheral blood of OSAHS patients has no correlation with BMI, age and gender (> 0.05), were positively correlated with AHI, negatively correlated with LSaO₂ (< 0.01). ③The CD69 expression rate of T cells and AHI in 27 cases of severe OSAHS patients with a comprehensive treatment has significantly reduced, LSaO₂ increased significantly (< 0.01).Increased expression of CD69 in peripheral blood T cells may be one of the mechanisms of OSAHS complicated with cardiovascular disease. Detection of CD69 expression rate in T cells for reflecting the degree of disease in patients with OSAHS, assessment of risk of cardiovascular damage, have certain clinical significance.
探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者外周血T细胞CD69表达情况及其意义。根据呼吸暂停低通气指数（AHI），将81例经多导睡眠图（PSG）确诊的OSAHS患者分为轻、中、重3组，每组27例；选取27例无OSAHS患者作为对照组。采用流式细胞术检测T细胞CD69表达率，分析T细胞CD69表达率与性别、年龄、体重指数（BMI）及PSG指标的相关性。①OSAHS患者外周血T细胞CD69表达率随打鼾程度加重而逐渐升高（P<0.05）；两两比较显示，对照组与轻度组T细胞CD69表达率差异无统计学意义（Z=1.649，P>0.05）；其他组间差异有统计学意义（P<0.05）。②OSAHS患者外周血T细胞CD69表达率与BMI、年龄及性别无相关性（P>0.05），与AHI呈正相关，与最低血氧饱和度（LSaO₂）呈负相关（P<0.01）。③27例重度OSAHS患者综合治疗后T细胞CD69表达率及AHI显著降低，LSaO₂显著升高（P<0.01）。外周血T细胞CD69表达增加可能是OSAHS并发心血管疾病的机制之一。检测T细胞CD69表达率对反映OSAHS患者病情程度、评估心血管损害风险具有一定临床意义。
