曲马唑嗪对充血性心力衰竭患者的慢性α-肾上腺素能受体阻滞作用
Chronic alpha-adrenoceptor blockade with trimazosin in congestive heart failure.
作者信息
Kirlin P C, Das S, Pitt B
出版信息
Int J Cardiol. 1985 May;8(1):89-92. doi: 10.1016/0167-5273(85)90267-0.
PMID:2987137
Abstract
We evaluated chronic adjunctive alpha-1 receptor blockade with trimazosin in congestive heart failure. This agent produced hemodynamic effects consistent with venodilation (reduced left ventricular volume and filling pressure with increased left ventricular ejection fraction), but only during exercise. Resting hemodynamic parameters and exercise duration were not significantly altered by chronic alpha-1 receptor blockade.
摘要
我们评估了曲马唑嗪对充血性心力衰竭患者进行长期辅助性α-1受体阻滞的效果。该药物产生了与静脉扩张相符的血流动力学效应（左心室容积和充盈压降低，左心室射血分数增加），但仅在运动期间出现。长期α-1受体阻滞对静息血流动力学参数和运动持续时间无显著影响。
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