Ishii D N, Recio-Pinto E, Spinelli W, Mill J F, Sonnenfeld K H
Int J Neurosci. 1985 Apr;26(1-2):109-27. doi: 10.3109/00207458508985610.
Until recently, nerve growth factor could be considered the only neurotrophic factor with an established physiological role. We discuss the emerging evidence indicating that the insulinlike factors may constitute a family of related neurotrophic proteins, and the observations suggesting that the receptor for the phorbol ester tumor promoters is closely associated with neuronal differentiation. The emphasis of the discussion is placed on neurite formation under multiple modulation by insulinlike factors, nerve growth factor, and tumor promoter receptors in sensory, sympathetic and human neuroblastoma cells.
直到最近，神经生长因子仍可被视为唯一具有确定生理作用的神经营养因子。我们讨论了新出现的证据，这些证据表明胰岛素样因子可能构成一个相关神经营养蛋白家族，以及那些表明佛波酯肿瘤启动子受体与神经元分化密切相关的观察结果。讨论重点在于感觉神经、交感神经和人神经母细胞瘤细胞中，胰岛素样因子、神经生长因子和肿瘤启动子受体在多重调节下的神经突形成。
