Kozlowska Elzbieta, Wysokinski Adam, Majewski Karol, Agier Justyna, Margulska Aleksandra, Brzezinska-Blaszczyk Ewa
Department of Experimental Immunology, Medical University of Lodz, Lodz, Poland.
J Biosci. 2018 Jun;43(2):321-327.
In addition to killing pathogens and influencing immunological processes, cathelicidin LL-37 is a multifunctional host defense peptide with a role in homeostasis. It has been suggested that imbalances in homeostatic signaling from inflammatory/ immune, endocrine and metabolic cascades and oxidative stress may partially contribute to the pathogenesis of mental disorders. The purpose of the study was to identify any differences in LL-37 levels between patients with schizophrenia, euthymic bipolar disorder, bacterial pneumonia, pulmonary tuberculosis, and healthy controls. Thirty-five patients with chronic paranoid schizophrenia, 40 patients with chronic, euthymic bipolar disorder, 30 patients with bacterial pneumonia, 32 patients with pulmonary tuberculosis, and 38 healthy volunteers were included in this study. The patients with schizophrenia demonstrated a significantly lower level of LL-37 than those with bipolar disorder (p=0.006) and those with pulmonary TB (p less than 0.001). Significant differences in LL-37 levels were found between patients with bipolar disorder, bacterial pneumonia (p less than 0.001) and pulmonary TB (p=0.004). Our findings suggest that changes observed in the serum level of LL-37 in psychiatric patients enrolled in this study could be a result of homeostatic imbalance.
除了杀死病原体和影响免疫过程外，cathelicidin LL-37是一种多功能宿主防御肽，在体内平衡中发挥作用。有人提出，炎症/免疫、内分泌和代谢级联反应以及氧化应激引起的体内平衡信号失衡可能部分导致精神障碍的发病机制。本研究的目的是确定精神分裂症患者、心境正常的双相情感障碍患者、细菌性肺炎患者、肺结核患者与健康对照者之间LL-37水平的差异。本研究纳入了35例慢性偏执型精神分裂症患者、40例慢性心境正常的双相情感障碍患者、30例细菌性肺炎患者、32例肺结核患者和38名健康志愿者。精神分裂症患者的LL-37水平显著低于双相情感障碍患者（p=0.006）和肺结核患者（p<0.001）。双相情感障碍患者与细菌性肺炎患者（p<0.001）以及肺结核患者（p=0.004）之间的LL-37水平存在显著差异。我们的研究结果表明，本研究中纳入的精神科患者血清LL-37水平的变化可能是体内平衡失衡的结果。
