抗菌肽cathelicidin在先天性肺炎中的诊断价值
Diagnostic value of anti-microbial peptide, cathelicidin in congenital pneumonia.
作者信息
Gad Ghada I, Abushady Nancy M, Fathi Marwa S, Elsaadany Wafaa
机构信息
a Department of Pediatrics and.
b Department of Medical Microbiology and Immunology, Faculty of Medicine , Ain Shams University , Cairo , Egypt.
出版信息
J Matern Fetal Neonatal Med. 2015;28(18):2197-200. doi: 10.3109/14767058.2014.981806. Epub 2014 Nov 27.
OBJECTIVE
To evaluate the diagnostic value of anti-microbial peptide (cathelicidin), LL-37, in congenital pneumonia and its relation to 25 hydroxycholecalciferol [(25 OH)D] status.
METHODS
The study included 30 neonates with congenital pneumonia and culture proven sepsis admitted to neonatal intensive care unit of Ain Shams University and 30 healthy neonates as control group. All neonates were subjected to history taking, clinical examination and measurement of serum 25(OH)D and cathelicidin.
RESULTS
Neonates with congenital pneumonia had significantly higher serum cathelicidin and lower serum 25(OH)D compared to controls. Serum cathelicidin was negatively correlated with Apgar score at 1 and 5 min and positively correlated with length of stay among patient group.
CONCLUSION
Cut-off value of cathelicidin to diagnose congenital pneumonia was 17 pg/mmol with 93% sensitivity and 86% specificity. Neonates with congenital pneumonia had significantly high cathelicidin and low 25(OH)D suggesting a possible role of fetal 25(OH)D deficiency as predisposing factor for congenital pneumonia.
目的
评估抗菌肽（cathelicidin）LL-37在先天性肺炎中的诊断价值及其与25-羟胆钙化醇[（25 OH）D]状态的关系。
方法
该研究纳入了30例入住艾因夏姆斯大学新生儿重症监护病房的先天性肺炎且血培养证实有败血症的新生儿，以及30例健康新生儿作为对照组。所有新生儿均接受病史采集、临床检查以及血清25（OH）D和cathelicidin的检测。
结果
与对照组相比，先天性肺炎新生儿的血清cathelicidin显著升高，血清25（OH）D降低。在患者组中，血清cathelicidin与1分钟和5分钟时的阿氏评分呈负相关，与住院时间呈正相关。
结论
cathelicidin诊断先天性肺炎的截断值为17 pg/mmol，敏感性为93%，特异性为86%。先天性肺炎新生儿的cathelicidin显著升高而25（OH）D降低，提示胎儿25（OH）D缺乏可能是先天性肺炎的易感因素。
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