人类急性髓细胞白血病细胞实施的抑制宿主免疫监视的生化机制。
Biochemical mechanisms implemented by human acute myeloid leukemia cells to suppress host immune surveillance.
机构信息
Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham Maritime, UK.
Department of Dermatology and Allergy, University of Oldenburg, Oldenburg, Germany.
出版信息
Cell Mol Immunol. 2018 Nov;15(11):989-991. doi: 10.1038/s41423-018-0047-6. Epub 2018 Jun 5.
Abstract
Acute myeloid leukaemia (AML) is a blood/bone marrow cancer originating from myeloid cell precusors capable of self-renewing. AML cells implement biochemical mechanisms which allow them not only to survive, but also to successfully escape immune surveillance. ln this work, we discuss crucial molecular mechanisms used by human AML cells in order to evade immune attack.
摘要
急性髓系白血病（AML）是一种起源于能够自我更新的髓系细胞前体的血液/骨髓癌。AML 细胞实施生化机制，不仅使它们能够存活，而且还能够成功逃避免疫监视。在这项工作中，我们讨论了人类 AML 细胞用于逃避免疫攻击的关键分子机制。
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