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被误诊为癌前病变的口腔结核

Tuberculosis of the Oral Cavity Misdiagnosed as Precancerous Lesion.

作者信息

Vučičević Boras Vanja, Gabrić Dragana, Smiljanić Tomičević Ljiljana, Seiwerth Sven, Gršić Krešimir, Šarčević Božena, Lončar Brzak Božana, Marunica Emilija, Glavina Ana

机构信息

Department of Oral Medicine, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

Department of Oral Surgery, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

出版信息

Acta Stomatol Croat. 2017 Dec;51(4):326-331. doi: 10.15644/asc51/4/7.

Abstract

INTRODUCTION

The aim of this case report was to discuss an extremely rare oral lesion as a result of primary pulmonary tuberculosis.

CASE REPORT

In this case report, the patient with refractory painless ulceration at ventral surface of the tongue was described. Detailed medical history was taken followed by clinical examination of the oral mucosa and palpation of regional lymph nodes. Clinical examination revealed ulceration on the patient's ventro-lateral surface of the tongue, approximately two centimeters in diameter. Palpation of regional lymph nodes has not revealed enlargement. The toluidine blue test of the suspected lesion was performed at each control examination. Biopsy samples for histopathologic diagnosis were taken three times. The analysis of the first biopsy sample for histopathology revealed a non-specific inflammation, the second biopsy revealed a caseous necrosis without positive Ziehl-Neelsen staining and the third biopsy revealed a granulomatous inflammation which was highly suspicious of sarcoidosis. During hospitalization, the patient underwent a complete physical examination, and laboratory and radiological diagnostics. Physical chest examination revealed bilaterally coarse crepitations and laboratory findings of his complete blood count revealed normocytic anemia of chronic disease. Radiographic examination of lungs showed multiple small nodules bilaterally and positive direct sputum smear.

CONCLUSION

Although oral tuberculosis is a rare condition, it must be taken into account in differential diagnosis of refractory painless oral ulcers.

摘要

引言

本病例报告的目的是讨论一例由原发性肺结核导致的极为罕见的口腔病变。

病例报告

在本病例报告中,描述了一名舌腹面出现难治性无痛性溃疡的患者。详细询问了病史,随后对口腔黏膜进行了临床检查并触诊了区域淋巴结。临床检查发现患者舌腹侧面有溃疡,直径约两厘米。区域淋巴结触诊未发现肿大。在每次复查时对疑似病变进行了甲苯胺蓝试验。进行了三次组织病理学诊断的活检取样。第一次活检样本的组织病理学分析显示为非特异性炎症,第二次活检显示为干酪样坏死但齐-尼氏染色阴性,第三次活检显示为肉芽肿性炎症,高度怀疑为结节病。住院期间,患者接受了全面的体格检查、实验室及影像学诊断。胸部体格检查发现双侧有粗大湿啰音,全血细胞计数的实验室检查结果显示为慢性病性正细胞性贫血。肺部影像学检查显示双侧有多个小结节,痰涂片直接检查呈阳性。

结论

尽管口腔结核是一种罕见疾病,但在难治性无痛性口腔溃疡的鉴别诊断中必须予以考虑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fd8/5975450/ca21f9809aca/ASC_51(4)_326-331-f1.jpg

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