皮肤自发荧光——一种评估心血管风险和糖尿病风险的非侵入性测量方法。
Skin Autofluorescence - A Non-invasive Measurement for Assessing Cardiovascular Risk and Risk of Diabetes.
作者信息
Stirban Alin, Heinemann Lutz
机构信息
Director Endocrinology and Diabetes Complications.
Senior Scientific Consultant, Profil, Neuss, Germany.
出版信息
Eur Endocrinol. 2014 Aug;10(2):106-110. doi: 10.17925/EE.2014.10.02.106. Epub 2014 Aug 28.
Abstract
The results of the Diabetes Control and Complications Trial-Epidemiology of Diabetes Interventions and Complications (DCCT-EDIC) study have strengthened the 'glycaemic memory' concept, postulating that the quality of metabolic control over several years predicts the development of diabetic complications. To mirror long-term metabolic control, the degree of glycated haemoglobin (HbA) might not represent the optimal biomarker. Other substances with a longer persistence, like the so-called advanced glycation end-products (AGEs), which probably form the substrate of the glycaemic memory, might perform better. Newly developed methods such as the assessment of skin autofluorescence (SAF), enable fast, uncomplicated and non-invasive AGEs assessment. SAF was validated for diabetes screening and shows a good predictive value for the development of diabetic and cardiovascular complications. This article deals with the theoretical background and with available clinical data on this new variable.
摘要
糖尿病控制与并发症试验-糖尿病干预与并发症流行病学（DCCT-EDIC）研究结果强化了“血糖记忆”概念，该概念假定数年的代谢控制质量可预测糖尿病并发症的发生。为反映长期代谢控制情况，糖化血红蛋白（HbA）水平可能并非最佳生物标志物。其他具有更长存留时间的物质，如所谓的晚期糖基化终产物（AGEs），可能构成血糖记忆的底物，或许表现更佳。新开发的方法，如皮肤自发荧光（SAF）评估，可实现快速、简便且无创的AGEs评估。SAF已被验证可用于糖尿病筛查，且对糖尿病及心血管并发症的发生具有良好的预测价值。本文探讨了这一新变量的理论背景及现有临床数据。
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