Ali Rizwan, Tahir Arooj, Posina Kanna V
Internal Medicine, Rapides Regional Hospital, Alexandria, La.
Cardiology, Rapides Regional Hospital, Alexandria, La.
Cureus. 2018 Apr 2;10(4):e2410. doi: 10.7759/cureus.2410.
Hyperthyroidism is a common metabolic disorder with many cardiovascular manifestations. In rare cases, untreated hyperthyroidism can lead to thyrotoxic cardiomyopathy with severe left ventricular (LV) dysfunction. This case report aims to discuss the pathogenesis of heart failure in hyperthyroidism and the available treatment options. A 51-year-old male with a past history of untreated hyperthyroidism presented to our hospital for the evaluation of shortness of breath and dysphagia. Workup revealed atrial flutter and severe biventricular dilated cardiomyopathy. Stabilization thyroidectomy was performed due to dysphagia, and treatment with oral antithyroid medications was initiated. The patient was discharged on synthroid and beta-blockers. Untreated hyperthyroidism can lead to biventricular failure even in the young. Untreated hyperthyroidism leads to significant mortality and morbidity. Untreated hyperthyroidism is associated with atrial fibrillation, heart failure, pulmonary hypertension (PH), and angina-like symptoms. Further studies should be done to evaluate the pathogenesis of Graves/Goiter hyperthyroidism and the least-invasive, safe, and definitive treatment options should be discovered. Current treatment options are limited and include medication that needs to be taken lifelong; they are associated with toxicity. Radioactive iodine ablation comes with the drawback of long-term replacement therapy. The last option is surgery, which is invasive and has its own complications.
甲状腺功能亢进症是一种常见的代谢紊乱疾病,有许多心血管方面的表现。在罕见情况下,未经治疗的甲状腺功能亢进症可导致甲状腺毒症性心肌病,并伴有严重的左心室功能障碍。本病例报告旨在探讨甲状腺功能亢进症中心力衰竭的发病机制以及现有的治疗选择。一名51岁男性,既往有未经治疗的甲状腺功能亢进症病史,因气短和吞咽困难到我院就诊。检查发现心房扑动和严重的双心室扩张型心肌病。由于吞咽困难进行了甲状腺切除术,并开始使用口服抗甲状腺药物治疗。患者出院时服用甲状腺素和β受体阻滞剂。即使在年轻人中,未经治疗的甲状腺功能亢进症也可导致双心室衰竭。未经治疗的甲状腺功能亢进症会导致显著的死亡率和发病率。未经治疗的甲状腺功能亢进症与心房颤动、心力衰竭、肺动脉高压(PH)及心绞痛样症状有关。应进一步开展研究以评估格雷夫斯病/甲状腺肿性甲状腺功能亢进症的发病机制,并应找到侵入性最小、安全且确定的治疗选择。目前的治疗选择有限,包括需要终身服用的药物,且这些药物具有毒性。放射性碘消融术存在长期替代治疗的缺点。最后一种选择是手术,它具有侵入性且有其自身的并发症。