宿主相关微生物群落中的信号传导。
Signaling in Host-Associated Microbial Communities.
作者信息
Fischbach Michael A, Segre Julia A
机构信息
Department of Bioengineering and Therapeutic Sciences and California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, USA.
Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA.
出版信息
Cell. 2016 Mar 10;164(6):1288-1300. doi: 10.1016/j.cell.2016.02.037.
Abstract
Human-associated microbiota form and stabilize communities based on interspecies interactions. We review how these microbe-microbe and microbe-host interactions are communicated to shape communities over a human's lifespan, including periods of health and disease. Modeling and dissecting signaling in host-associated communities is crucial to understand their function and will open the door to therapies that prevent or correct microbial community dysfunction to promote health and treat disease.
摘要
与人类相关的微生物群基于种间相互作用形成并稳定群落。我们回顾了这些微生物与微生物以及微生物与宿主之间的相互作用如何在人类的整个生命周期中进行传递，从而塑造群落，包括健康和疾病时期。对宿主相关群落中的信号传导进行建模和剖析对于理解其功能至关重要，并且将为预防或纠正微生物群落功能障碍以促进健康和治疗疾病的疗法打开大门。
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本文引用的文献
1
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Science. 2016 Jan 15;351(6270):224-6. doi: 10.1126/science.aad6753.
2
Diet-induced extinctions in the gut microbiota compound over generations.饮食导致的肠道微生物群灭绝会在几代人之间不断加剧。
Nature. 2016 Jan 14;529(7585):212-5. doi: 10.1038/nature16504.
3
Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis.肠道微生物三甲胺生成的非致死性抑制用于动脉粥样硬化的治疗
Cell. 2015 Dec 17;163(7):1585-95. doi: 10.1016/j.cell.2015.11.055.
4
Personalized Nutrition by Prediction of Glycemic Responses.基于血糖反应预测的个性化营养。
Cell. 2015 Nov 19;163(5):1079-1094. doi: 10.1016/j.cell.2015.11.001.
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A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes.调节性T细胞涌入新生儿皮肤介导对共生微生物的耐受性。
Immunity. 2015 Nov 17;43(5):1011-21. doi: 10.1016/j.immuni.2015.10.016.
6
The ecology of the microbiome: Networks, competition, and stability.微生物组的生态学：网络、竞争与稳定性。
Science. 2015 Nov 6;350(6261):663-6. doi: 10.1126/science.aad2602.
7
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8
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9
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Cell Host Microbe. 2015 Nov 11;18(5):582-92. doi: 10.1016/j.chom.2015.10.007. Epub 2015 Oct 29.
10
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Cell Host Microbe. 2015 Oct 14;18(4):489-500. doi: 10.1016/j.chom.2015.09.008.
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