Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Chem Commun (Camb). 2018 Jun 21;54(51):7034-7037. doi: 10.1039/c8cc03856b.
The Ph3P/ICH2CH2I system-promoted dehydroxylative substitution of alcohols was achieved to construct C-O, C-N, C-S and C-X (X = Cl, Br, and I) bonds. Compared with the previous approaches such as the Appel reaction and Mitsunobu reaction, this protocol offers some practical advantages such as safe operation and a convenient amination process.
Ph3P/ICH2CH2I 体系促进的醇的脱氢羟基取代反应可用于构建 C-O、C-N、C-S 和 C-X（X = Cl、Br 和 I）键。与 Appel 反应和 Mitsunobu 反应等先前的方法相比，该方法具有安全操作和方便的胺化过程等实际优势。
