School of Metallurgical and Chemical Engineering, Jiangxi University of Science and Technology, 86 Hongqi Road, Ganzhou 341000, China.
Org Biomol Chem. 2018 Jun 20;16(24):4501-4508. doi: 10.1039/c8ob00779a.
A TBAB-mediated brominative 5-exo-dig oxy-cyclization of 2-alkynylbenzamide is described here for the synthesis of isobenzofuran-1-imines and isobenzofuran derivatives at room temperature with a high efficiency and a broad reaction scope. The resulting isobenzofuran derivatives are also applied for synthesising various substituted isobenzofuran derivatives.
本文报道了一种在室温下通过 TBAB 介导的 2-炔基苯甲酰胺的溴代 5-endo-dig 氧环化反应，高效、高区域选择性地合成了异苯并呋喃-1-亚胺和异苯并呋喃衍生物。所得的异苯并呋喃衍生物也可用于合成各种取代的异苯并呋喃衍生物。
