关于光敏剂纳米载体在光动力疗法中作用的见解。
An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy.
作者信息
Mesquita Mariana Q, Dias Cristina J, Gamelas Sara, Fardilha Margarida, Neves Maria G P M S, Faustino Maria Amparo F
机构信息
Department of Chemistry and QOPNA, University of Aveiro, Aveiro, Portugal.
Department of Biomedical Sciences, University of Aveiro, Aveiro, Portugal.
出版信息
An Acad Bras Cienc. 2018;90(1 Suppl 2):1101-1130. doi: 10.1590/0001-3765201720170800.
Photodynamic therapy (PDT) is a modality of cancer treatment in which tumor cells are destroyed by reactive oxygen species (ROS) produced by photosensitizers following its activation with visible or near infrared light. The PDT success is dependent on different factors namely on the efficiency of the photosensitizer deliver and targeting ability. In this review a special attention will be given to the role of some drug delivery systems to improve the efficiency of tetrapyrrolic photosensitizers to this type of treatment.
光动力疗法（PDT）是一种癌症治疗方式，其中肿瘤细胞被光敏剂在可见光或近红外光激活后产生的活性氧（ROS）所破坏。PDT的成功取决于不同因素，即光敏剂递送效率和靶向能力。在本综述中，将特别关注一些药物递送系统在提高四吡咯类光敏剂用于此类治疗的效率方面的作用。
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