Monash University, Clayton, Victoria, Australia.
Monash Infectious Diseases, Monash Health, Clayton, Victoria, Australia.
J Antimicrob Chemother. 2018 Oct 1;73(10):2601-2612. doi: 10.1093/jac/dky174.
The decision to prescribe long-term or 'life-long' antibiotics in patients requires careful consideration by the treating clinician. While several guidelines exist to help assist in this decision, the long-term consequences are yet to be well studied. In this review, we aim to provide a summary of the available evidence for patient populations where long-term antibiotic therapy is currently recommended in clinical practice. We will also discuss the pitfalls of this approach, including medication adverse effects, economic cost and any possible contribution to the emerging epidemic of microbial resistance.
在为患者开具长期或“终身”抗生素时，治疗医生需要仔细考虑。尽管有一些指南可以帮助做出这一决定，但长期后果尚未得到很好的研究。在这篇综述中，我们旨在为目前在临床实践中推荐长期抗生素治疗的患者人群提供现有证据的概述。我们还将讨论这种方法的缺陷，包括药物不良反应、经济成本以及对新兴微生物耐药性流行的可能贡献。
