Walter Brendel Centre of Experimental Medicine, Biomedical Center, Ludwig-Maximilians-Universität München, Munich, Germany.
Department of Biomedical Engineering, Graduate Group in Immunology, University of California, Davis, CA, USA.
Eur J Clin Invest. 2018 Nov;48 Suppl 2(Suppl 2):e12964. doi: 10.1111/eci.12964. Epub 2018 Jun 22.
The recruitment of neutrophils to sites of inflammation, their battle against invading microorganisms through phagocytosis and the release of antimicrobial agents is a highly coordinated and tightly regulated process that involves the interplay of many different receptors, ion channels and signalling pathways. Changes in intracellular calcium levels, caused by cytosolic Ca store depletion and the influx of extracellular Ca via ion channels, play a critical role in synchronizing neutrophil activation and function. In this review, we provide an overview of how Ca signalling is initiated in neutrophils and how changes in intracellular Ca levels modulate neutrophil function.
中性粒细胞向炎症部位的募集、通过吞噬作用和释放抗菌剂与入侵微生物进行战斗，是一个高度协调和严格调控的过程，涉及许多不同的受体、离子通道和信号通路的相互作用。细胞内钙离子水平的变化，是由细胞质内钙库耗竭和离子通道介导的细胞外钙内流引起的，在协调中性粒细胞的激活和功能中起着关键作用。在这篇综述中，我们概述了中性粒细胞中钙信号的启动方式，以及细胞内钙离子水平的变化如何调节中性粒细胞的功能。
