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“火星-500”项目中盐摄入量受控情况下尿液的蛋白质组学分析

PROTEOMIC ANALYSIS OF URINE UNDER CONTROLLED SALT INTAKE IN PROJECT <<MARS-500>>.

作者信息

Pastushkova L Kh, Kashirina D N, Kononikhin A S, Starodubtseva N L, Dobrokhotov I V, Tiys E S, Larina I M

出版信息

Aviakosm Ekolog Med. 2016;50(4):21-26. doi: 10.21687/0233-528x-2016-50-4-21-26.

DOI:10.21687/0233-528x-2016-50-4-21-26
PMID:29873977
Abstract

Specifics of urine proteome is sensitive to a multitude of factors. One is nutrition or entrance in organism of main nutrients including salt (NaCI). Purpose of the investigation was to study the proteomic composition of healthy human urine in the controlled environment of a 105-day isolation experiment (project <>) with various levels of salt intake. Analysis was performed using the present-day proteomics techniques based on chromatography-mass spectrometry and bio-informatics options. An attempt was made to correlate changes in processes and physiological systems with the controlled salt intake. As a result, a list of proteins directly responsible for different salt intake during the experiment and then a list of tissues where these proteins express predominantly were compiled; besides, analysis of the processes these proteins are involved in was performed.

摘要

尿液蛋白质组的特性对多种因素敏感。其中一个因素是营养或主要营养物质（包括盐（氯化钠））进入机体。本研究的目的是在105天隔离实验（“火星-500”项目）的可控环境中，研究不同盐摄入量下健康人尿液的蛋白质组组成。使用基于色谱-质谱联用和生物信息学方法的当代蛋白质组学技术进行分析。试图将生理过程和系统的变化与可控的盐摄入量相关联。结果，编制了一份在实验期间直接对应不同盐摄入量的蛋白质清单，以及一份这些蛋白质主要表达的组织清单；此外，还对这些蛋白质所参与的过程进行了分析。

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