[2,3-Dihydro-1H-pyrrolo[3,2-c]quinoline and 2,3,5,9b-tetrahydro-1H-pyrrolo[3,2-c]-quinoline derivatives:synthesis and their inhibitory activity against Kv2.1].

Fourteen new compounds with 2,3-dihydro-1H-pyrrolo[3,2-c]-quinoline or 2,3,5,9b-tetrahydro-1H-pyrrolo[3,2-c]quinoline scaffold were designed and synthesized, and their inhibitory activities against Kv2.1 were evaluated. As a result,2,3-dihydro-1H-pyrrolo[3,2-c]quinoline derivatives 3a and 5a were identified as potent inhibitors of Kv2.1 with IC(50) values of 10.2 and 9.0 μmol·L(-1), respectively.