1H-吡咯并[3,2-g]喹啉-4,9-二酮和4,9-二氧代-4,9-二氢-1H-苯并[f]吲哚的合成及抗真菌活性
Synthesis and antifungal activity of 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles.
作者信息
Ryu Chung-Kyu, Lee Jung Yoon, Jeong Seong Hee, Nho Ji-Hee
机构信息
College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2009 Jan 1;19(1):146-8. doi: 10.1016/j.bmcl.2008.10.131. Epub 2008 Nov 5.
1H-Pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles were synthesized and tested for in vitro antifungal activity against fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles would be potent antifungal agents.
合成了1H-吡咯并[3,2-g]喹啉-4,9-二酮和4,9-二氧代-4,9-二氢-1H-苯并[f]吲哚，并对其进行了抗真菌体外活性测试。在测试的这些化合物中，许多化合物显示出良好的抗真菌活性。结果表明，1H-吡咯并[3,2-g]喹啉-4,9-二酮和4,9-二氧代-4,9-二氢-1H-苯并[f]吲哚可能是有效的抗真菌剂。
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