Department of Medical Biochemistry, Semmelweis University, Budapest 1094, Hungary.
Cell Metab. 2018 Jun 5;27(6):1165-1167. doi: 10.1016/j.cmet.2018.05.010.
Mutations in mtDNA associated with OXPHOS defects preclude energy harnessing by OXPHOS. The work of Chen et al. (2018) is previewed, reporting flux pathways of glutamine catabolism in mtDNA mutant cells yielding high-energy phosphates through substrate-level phosphorylation and the influence exerted by the severity of OXPHOS impairment.
与 OXPHOS 缺陷相关的 mtDNA 突变排除了 OXPHOS 通过能量收集。Chen 等人的工作（2018）被预览，报告了 mtDNA 突变细胞中谷氨酰胺分解代谢的通量途径，通过底物水平磷酸化产生高能磷酸化合物，以及 OXPHOS 损伤严重程度的影响。
