研究控制能量平衡的大脑机制的病毒载体。

Viral Vectors for Studying Brain Mechanisms that Control Energy Homeostasis.

机构信息

Program in Integrative Cell Signalling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

Program in Integrative Cell Signalling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Anatomy and Histology, University of Veterinary Medicine, Budapest 1078, Hungary.

出版信息

Cell Metab. 2018 Jun 5;27(6):1168-1175. doi: 10.1016/j.cmet.2018.05.015.

DOI:10.1016/j.cmet.2018.05.015

PMID:29874565

Abstract

Viral vectors have been shown to be potent and versatile tools for genome editing. In the present Minireview, we focus on lentiviruses and adeno-associated viruses as vectors and their use in the study of the hypothalamic circuits involved in the regulation of energy homeostasis.

摘要

病毒载体已被证明是基因组编辑的有效且多功能的工具。在本次迷你综述中，我们专注于慢病毒和腺相关病毒作为载体及其在研究参与能量稳态调节的下丘脑回路中的应用。