State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Key Laboratory for Aging and Regenerative Medicine, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China.
Molecules. 2018 Jun 5;23(6):1359. doi: 10.3390/molecules23061359.
Aging is a major risk factor for many prevalent diseases. Pharmacological intervention to improve the health span and extend the lifespan could be a preventive elixir for aging and age-related diseases. The non-steroid anti-inflammation medicine aspirin was reported to delay aging in () and mice. We are wondering if the analogues of aspirin could also present antiaging activity. Here, we synthesized several aspirin derivatives and investigated their thermotolerance and antiaging effect in . One of the compounds, 5-(bis(3-methylbut-2-en-1-yl)amino)-2-hydroxybenzoic acid, moderately increased the survival of under heat stress, but could not extend the lifespan under optimum conditions. This compound could increase the mRNA level of stress response gene , and the mRNA and protein expression level of heat shock protein under heat stress. The failure of activating the transcription factor DAF-16 might explain why this compound could not act as aspirin to extend the lifespan of . Our results would help further the investigation of the pharmacological activity of aspirin analogues and the relationship between structures and activity.
衰老是许多常见疾病的主要危险因素。改善健康寿命和延长寿命的药物干预可能是预防衰老和与衰老相关疾病的预防灵丹妙药。非甾体抗炎药阿司匹林被报道能延缓 () 和小鼠的衰老。我们想知道阿司匹林的类似物是否也具有抗衰老活性。在这里，我们合成了几种阿司匹林衍生物，并在 中研究了它们的耐热性和抗衰老作用。其中一种化合物，5-（双（3-甲基-2-丁烯-1-基）氨基）-2-羟基苯甲酸，适度提高了热应激下 的存活率，但不能延长最佳条件下的寿命。这种化合物可以增加应激反应基因 的 mRNA 水平，以及热休克蛋白在热应激下的 mRNA 和蛋白表达水平。转录因子 DAF-16 的激活失败可能解释了为什么这种化合物不能像阿司匹林那样延长 的寿命。我们的结果将有助于进一步研究阿司匹林类似物的药理活性以及结构与活性之间的关系。
