Barardo Diogo, Thornton Daniel, Thoppil Harikrishnan, Walsh Michael, Sharifi Samim, Ferreira Susana, Anžič Andreja, Fernandes Maria, Monteiro Patrick, Grum Tjaša, Cordeiro Rui, De-Souza Evandro Araújo, Budovsky Arie, Araujo Natali, Gruber Jan, Petrascheck Michael, Fraifeld Vadim E, Zhavoronkov Alexander, Moskalev Alexey, de Magalhães João Pedro
Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham (Amrita University), Coimbatore, India.
Aging Cell. 2017 Jun;16(3):594-597. doi: 10.1111/acel.12585. Epub 2017 Mar 16.
Aging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds that extend lifespan in model organisms is a growing research area. Here, we present DrugAge (http://genomics.senescence.info/drugs/), a curated database of lifespan-extending drugs and compounds. At the time of writing, DrugAge contains 1316 entries featuring 418 different compounds from studies across 27 model organisms, including worms, flies, yeast and mice. Data were manually curated from 324 publications. Using drug-gene interaction data, we also performed a functional enrichment analysis of targets of lifespan-extending drugs. Enriched terms include various functional categories related to glutathione and antioxidant activity, ion transport and metabolic processes. In addition, we found a modest but significant overlap between targets of lifespan-extending drugs and known aging-related genes, suggesting that some but not most aging-related pathways have been targeted pharmacologically in longevity studies. DrugAge is freely available online for the scientific community and will be an important resource for biogerontologists.
衰老在全球范围内是一项重大的医学挑战。毫不奇怪，在模式生物中鉴定能够延长寿命的药物和化合物是一个不断发展的研究领域。在此，我们展示了DrugAge（http://genomics.senescence.info/drugs/），这是一个经过整理的延长寿命药物和化合物数据库。在撰写本文时，DrugAge包含1316条记录，涵盖来自27种模式生物（包括线虫、果蝇、酵母和小鼠）研究中的418种不同化合物。数据是从324篇出版物中手动整理而来的。利用药物-基因相互作用数据，我们还对延长寿命药物的靶点进行了功能富集分析。富集的术语包括与谷胱甘肽和抗氧化活性、离子转运及代谢过程相关的各种功能类别。此外，我们发现延长寿命药物的靶点与已知衰老相关基因之间存在适度但显著的重叠，这表明在长寿研究中，一些但并非大多数衰老相关途径已成为药物作用靶点。DrugAge可供科学界免费在线使用，将成为生物老年学家的重要资源。
