Blumenfeld Z, Kerner H, Makler A, Eshkol A, Brandes J M
J Reprod Med. 1985 Mar;30(3):211-6.
About 120 cases of XY gonadal dysgenesis have been reported on. We treated such a patient with bilateral gonadectomy. The gonadal tissue's capacity to respond to hormonal trophic stimulation was assessed. When the gonads were examined ultrastructurally, structures with the morphologic characteristics of stromal ovarian cells, Sertoli's cells and Leydig's cells were found. Because of the potential malignancy of the XY gonads, bilateral gonadectomy and hormonal substitution therapy are recommended for these patients. We prefer to use combined hormone replacement with sequential estrogen and progesterone rather than sequential unopposed estrogen because of the small but increased risk of endometrial hyperplasia and carcinoma after long-standing sequential therapy.
已报道了约120例XY性腺发育不全病例。我们对一名此类患者进行了双侧性腺切除术。评估了性腺组织对激素营养刺激的反应能力。对性腺进行超微结构检查时，发现了具有基质卵巢细胞、支持细胞和间质细胞形态特征的结构。由于XY性腺存在潜在恶性风险，建议对这些患者进行双侧性腺切除术及激素替代治疗。由于长期序贯治疗后子宫内膜增生和癌的风险虽小但有所增加，我们更倾向于使用雌激素和孕激素序贯联合激素替代疗法，而非单纯序贯雌激素疗法。
