López Alfonso, McKenna Shawn
Departments of Pathology and Microbiology (Lopez), Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PEI, Canada.
Health Management (McKenna), Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PEI, Canada.
J Vet Diagn Invest. 2018 Sep;30(5):760-762. doi: 10.1177/1040638718780190. Epub 2018 Jun 7.
An 8-y-old lactating Holstein cow was presented to the herd veterinarian with a history of acute ataxia, and because of poor prognosis, the animal was euthanized and submitted for postmortem examination. A lumbar vertebra was incompletely fractured and had an adjacent subdural hematoma. The pancreas had a hard texture with exaggerated nodular appearance, and on cut surface, the pancreatic ducts appeared fibrotic and contained scores of round-to-faceted pancreatoliths of 0.5-2.0 mm diameter. These calculi extended from the major ducts to the pancreatic duct, sphincter, and into the duodenal lumen. Microscopically, the pancreas had severe acinar atrophy and dissecting glandular fibrosis. The major pancreatic ducts were ulcerated with fibrosis and inflammation. In humans, chronic pancreatitis has been linked to osteoporosis and increased risk of bone fractures. Manual evaluation of ribs at the time of autopsy did not reveal abnormalities in bone pliability or fragility in our cow.
一头8岁的泌乳期荷斯坦奶牛被送至兽群兽医处，有急性共济失调病史，由于预后不良，该动物被实施安乐死并进行尸体剖检。一个腰椎不完全骨折，并有相邻的硬膜下血肿。胰腺质地坚硬，结节外观明显，切面显示胰管纤维化，含有数十个直径为0.5 - 2.0毫米的圆形至多面形胰石。这些结石从主胰管延伸至胰腺导管、括约肌，并进入十二指肠腔。显微镜下，胰腺有严重的腺泡萎缩和腺内纤维化。主要胰管有溃疡，伴有纤维化和炎症。在人类中，慢性胰腺炎与骨质疏松症和骨折风险增加有关。尸检时对肋骨的手动评估未发现我们这头奶牛的骨骼柔韧性或脆性有异常。
