基因多态性在巴塔克族男性吸烟者尼古丁依赖和烟草消费中的作用
The Role of Genetic Polymorphism in Nicotine Dependence and Tobacco Consumption among Bataknese Male Smokers.
作者信息
Soeroso Noni Novisari, Zain-Hamid Rozaimah, Sinaga Bintang Y M, Sadewa Ahmad Hamim, Syafiuddin Tamsil, Syahruddin Elisna, Tann Gino, Mutiara Erna
机构信息
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Sumatera Utara, Jl. Dr Mansyur No.5 Medan 20155, Indonesia.
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Sumatera Utara, Jl. Dr Mansyur No.5 Medan 20155, Indonesia.
出版信息
Open Access Maced J Med Sci. 2018 May 19;6(5):864-866. doi: 10.3889/oamjms.2018.224. eCollection 2018 May 20.
AIM
This research aimed to analyse the relationship between CYP2A6 gene polymorphism with nicotine dependence and its relation to the number of cigarette consumption among Bataknese smokers.
METHOD
This study was a cross-sectional study involving 140 research subjects in Medan, Indonesia.
RESULTS
Nicotine dependence rates were found to be significantly associated with the number of cigarette consumption expressed in the Brinkman Index.
CONCLUSION
The *1A wild-type alleles have a greater risk of high-very high dependence rate compared to the other variants.
目的
本研究旨在分析多巴塔克族吸烟者中CYP2A6基因多态性与尼古丁依赖之间的关系及其与吸烟量的关系。
方法
本研究为横断面研究，涉及印度尼西亚棉兰的140名研究对象。
结果
发现尼古丁依赖率与布林克曼指数所表示的吸烟量显著相关。
结论
与其他变体相比，*1A野生型等位基因具有更高的高 - 极高依赖率风险。
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