Jang Sujeong, Jeong Han-Seong
Department of Physiology, Chonnam National University Medical School, Gwangju 61469, Republic of Korea.
Data Brief. 2018 Feb 27;17:1314-1319. doi: 10.1016/j.dib.2018.02.058. eCollection 2018 Apr.
This data article contains descriptive and experimental data on ion channel gene expressions following the histone deacetylase (HDAC) inhibitor treatment of neural induced human adipose tissue-derived mesenchymal stem cells (NI-hADSCs). Following treatment of the HDAC inhibitors, such as MS-275, NaB, TSA, or VPA, the phenotypes of NI-hADSCs exhibit neuron-like features and the neurofilament-L (NFL)-positive cells were increased. The expression of the ion channel marker genes, such as , , and , was highly increased following treatment with the HDAC inhibitors; however, the expression of others was either decreased or unchanged. For further details and experimental findings please refer to the research article by Jang and Jeong. Histone deacetylase inhibition-mediated neuronal differentiation via the Wnt signaling pathway in human adipose tissue-derived mesenchymal stem cells (Jang and Jeong, 2018) [1].
本文提供了关于组蛋白去乙酰化酶（HDAC）抑制剂处理神经诱导的人脂肪组织来源间充质干细胞（NI-hADSCs）后离子通道基因表达的描述性和实验性数据。在用HDAC抑制剂（如MS-275、NaB、TSA或VPA）处理后，NI-hADSCs的表型呈现出神经元样特征，且神经丝-L（NFL）阳性细胞增加。在用HDAC抑制剂处理后，离子通道标记基因（如 、 和 ）的表达显著增加；然而，其他基因的表达要么降低要么不变。有关更多详细信息和实验结果，请参阅Jang和Jeong的研究文章。人脂肪组织来源间充质干细胞中组蛋白去乙酰化酶抑制通过Wnt信号通路介导神经元分化（Jang和Jeong，2018年）[1]。
