一只受困扰的野兽：在T细胞肿瘤中靶向信号转导和转录激活因子5B（STAT5B）
A haunted beast: Targeting STAT5B in T-Cell Neoplasia.
作者信息
Pham Ha Thi Thanh, Hengstschläger Markus, Moriggl Richard
机构信息
Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria.
出版信息
Mol Cell Oncol. 2018 Mar 28;5(3):e1435181. doi: 10.1080/23723556.2018.1435181. eCollection 2018.
The somatic hot spot mutation STAT5B was found in many T cell leukemia/lymphoma patients. We generated and analyzed a transgenic mouse model with hematopoietic STAT5B expression that caused aggressive T-cell leukemia/lymphomas. Herein, we discuss the scientific merit of our model and its relevance for pre-clinical studies.
在许多T细胞白血病/淋巴瘤患者中发现了体细胞热点突变STAT5B。我们构建并分析了一种造血细胞表达STAT5B的转基因小鼠模型，该模型引发了侵袭性T细胞白血病/淋巴瘤。在此，我们讨论了我们模型的科学价值及其与临床前研究的相关性。
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