Li Zhihui, Sun Qinge, Huang Xiaoyan, Zhang Jianzhong, Hao Jing, Li Yue, Zhang Shihong
Department of Obstetrics and Gynecology Affiliated Hospital of Beihua University, Jilin, 132000, China.
Department of Gynecology Weihai Municipal Hospital, Shandong, 264200, China.
Open Med (Wars). 2018 Jun 1;13:83-89. doi: 10.1515/med-2018-0013. eCollection 2018.
This study investigated the effect of radiofrequency hyperthermia combined with chemotherapy in the treatment of advanced ovarian cancer.
Seventy-five patients with advanced ovarian cancer were grouped into observation (n = 36) and control (n = 37) groups according to different treatment methods. The age of the patients in the control and the experimental groups were (55 + 11) and (53 + 12) years old, respectively. The control group was received chemotherapy alone (paclitaxel + cisplatin chemotherapy), and on the basis of systemic chemotherapy, the observation group was administered therapy in conjunction with abdominal pelvic radiofrequency hyperthermia.
The tumor remission rate, ascites, serum CA125 levels, pain control, quality of life enhancement, III+IV bone marrow suppression and improvement of gastrointestinal reaction in the observation group were better than those of the control group (all P< 0.05).
Radiofrequency hyperthermia combined with chemotherapy in the treatment of advanced ovarian cancer has significantly improved the tumor remission rate, ascite control and CA125 levels, and substantially reduced the gastrointestinal reaction and bone marrow suppression rate, which is worthy of intensive clinical application.
本研究调查了射频热疗联合化疗治疗晚期卵巢癌的效果。
75例晚期卵巢癌患者根据不同治疗方法分为观察组（n = 36）和对照组（n = 37）。对照组和实验组患者的年龄分别为（55±11）岁和（53±12）岁。对照组仅接受化疗（紫杉醇+顺铂化疗），观察组在全身化疗的基础上联合腹部盆腔射频热疗。
观察组的肿瘤缓解率、腹水、血清CA125水平、疼痛控制、生活质量改善、III+IV度骨髓抑制及胃肠道反应改善情况均优于对照组（均P<0.05）。
射频热疗联合化疗治疗晚期卵巢癌显著提高了肿瘤缓解率、腹水控制率及CA125水平，并大幅降低了胃肠道反应和骨髓抑制率，值得临床深入应用。
