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母源免疫对乳鼠感染鼠冠状病毒JHM结果的影响。

Influence of maternal immunity on the outcome of murine coronavirus JHM infection in suckling mice.

作者信息

Pickel K, Müller M A, ter Meulen V

出版信息

Med Microbiol Immunol. 1985;174(1):15-24. doi: 10.1007/BF02123666.

DOI:10.1007/BF02123666
PMID:2987653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7087257/
Abstract

Adult C3H mice are resistant to intraperitoneal infection with murine coronavirus JHM, whereas suckling offspring of non-immune females are susceptible. Resistance can be conferred on suckling C3H mice by postnatal transmission of maternal immunity, if transfer precedes infection. Suckling mice succumb to infection even when they receive maternal antibodies within 1 day after infection. Prenatal transmission alone without subsequent postnatal transmission of maternal immunity is not sufficient to provide resistance. Persistence of virus without clinical consequences was observed when the supply of breast milk anti-JHMV antibodies was terminated 5 days before infection. Immune reactions restricted by histocompatibility antigens do not play a crucial role in bestowing resistance. As neutralizing anti-JHM serum antibody titers of adult mice only rise sharply 5 to 7 days after infection, these results indicate that infection of adults can be arrested by immunological means but that, in addition, the rate of virus dissemination must be limited by other non-immunological mechanisms.

摘要

成年C3H小鼠对鼠冠状病毒JHM的腹腔感染具有抵抗力，而非免疫雌性小鼠的乳鼠则易感。如果在感染前进行母源免疫的产后传递，可使乳鼠C3H小鼠获得抵抗力。即使乳鼠在感染后1天内接受母源抗体，它们仍会死于感染。仅产前传递而无随后的母源免疫产后传递不足以提供抵抗力。当在感染前5天终止母乳抗JHMV抗体供应时，观察到病毒持续存在但无临床后果。受组织相容性抗原限制的免疫反应在赋予抵抗力方面不起关键作用。由于成年小鼠的中和抗JHM血清抗体滴度仅在感染后5至7天急剧上升，这些结果表明，成年小鼠的感染可以通过免疫手段阻止，但此外，病毒传播速率必须受到其他非免疫机制的限制。

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