以大鼠的JHM感染作为急性和亚急性脱髓鞘疾病的模型。

JHM infections in rats as a model for acute and subacute demyelinating disease.

作者信息

Wege H, Koga M, Wege H, ter Meulen V

出版信息

Adv Exp Med Biol. 1981;142:327-40. doi: 10.1007/978-1-4757-0456-3_27.

Abstract

An animal model with different central nervous system (CNS) disease processes associated with demyelination is described which provides a basis to analyse the pathogenetic mechanisms leading to these disorders. Intracerebral infection of rats with the murine coronavirus strain JHM can result in an acute encephalomyelitis with a short incubation period or in subacute to chronic encephalomyelitis occurring after prolonged incubation. The most prominent finding of the latter two diseases consists of typical demyelinated lesions distributed in selected areas of the CNS. The induction of high rates of animals with demyelination depends both on properties of the virus used for infection and host factors such as age and immune status. A high number of rats with demyelination was obtained by intracerebral inoculation of temperature sensitive mutants into suckling rats with maternal JHM antibodies.

摘要

描述了一种与脱髓鞘相关的具有不同中枢神经系统（CNS）疾病过程的动物模型，该模型为分析导致这些疾病的发病机制提供了基础。用鼠冠状病毒株JHM对大鼠进行脑内感染可导致潜伏期短的急性脑脊髓炎，或在长时间潜伏期后发生亚急性至慢性脑脊髓炎。后两种疾病最显著的发现是在中枢神经系统的特定区域分布有典型的脱髓鞘病变。脱髓鞘动物高发生率的诱导既取决于用于感染的病毒特性，也取决于宿主因素，如年龄和免疫状态。通过将温度敏感突变体脑内接种到具有母体JHM抗体的乳鼠中，获得了大量脱髓鞘大鼠。