School of Medicine, Section of Bariatric and Minimally Invasive Surgery, Stanford University, 900 Blake Wilbur Drive, Room W0048, Stanford, CA, 94305, USA.
Obes Surg. 2018 Aug;28(8):2578-2582. doi: 10.1007/s11695-018-3317-6.
Cerebral cortical thickness is associated with memory and intelligence test scores and serves as a measure for changes in cortical gray matter. Previous studies suggest reduced cortical thickness in patients with obesity. This study aimed to investigate changes in cortical thickness following bariatric surgery. Magnetic resonance imaging (MRI) data of five patients were analyzed preoperatively and 6 months postoperatively to assess changes in global measures of cortical thickness. No patients were lost to follow-up. This study provides preliminary evidence of brain change following surgery, suggests increases in cerebral cortical thickness in patients with greater excess weight loss, and indicates the need for further investigation using larger samples and correlation with neurocognitive measures, such as memory recall.
大脑皮质厚度与记忆和智力测试分数相关，可作为皮质灰质变化的衡量指标。先前的研究表明，肥胖患者的皮质厚度降低。本研究旨在探讨减肥手术后大脑皮质厚度的变化。对五名患者的磁共振成像（MRI）数据进行了术前和术后 6 个月的分析，以评估皮质厚度的整体变化。没有患者失访。本研究初步证明了手术后大脑的变化，提示体重减轻更多的患者大脑皮质厚度增加，并表明需要使用更大的样本量和与记忆等神经认知测量相关的进一步研究。
