Khoueir Paul, Black Mary Helen, Crookes Peter F, Kaufman Howard S, Katkhouda Namir, Wang Michael Y
Department of Neurological Surgery, Hôpital Sacré-Coeur, Université de Montréal, 5400 Boulevard, Gouin O., Montréal, Québec H4J 1C5, Canada.
Spine J. 2009 Jun;9(6):454-63. doi: 10.1016/j.spinee.2009.02.003. Epub 2009 Apr 8.
The prevalence of obesity in developed countries has reached alarming levels, doubling in the United States since 1980. Although obese patients with chronic low back pain are frequently advised to lose weight, the association between these medical conditions remains unproven.
This study prospectively assessed clinically reported changes in chronic axial low back pain symptoms after weight reduction from bariatric surgery for morbid obesity.
Prospective longitudinal study.
Fifty-eight consecutive patients with morbid obesity and chronic axial low back pain undergoing bariatric surgery over a period of 6 months. Patients were considered morbidly obese if they were 50% to 100% above their ideal body weight or having a body mass index (BMI) greater than 40.
Visual Analog Scale (VAS) for axial low back pain, Short Form-36 (SF-36) Health Survey, and Oswestry Disability Index (ODI) METHODS: Patients undergoing weight reduction surgery were assessed preoperatively and postoperatively at 12 months with validated clinical measures for axial back pain and disability (VAS, SF-36, and ODI). Bariatric surgery parameters included demographic data, weight, and BMI. Statistical analysis included paired t tests and multiple regression techniques.
Of the initial 58 patients, 38 (65%) completed both preoperative (Pre-Op) and postoperative (Post-Op) questionnaires at 12 months. These 38 subjects included 30 women and 8 men, with an age range of 20 to 68 years (mean 48.4+/-10.1). Overall, these patients showed a decrease in mean weight from 144.52+/-41.21kg Pre-Op to 105.59+/-29.24 Post-Op (p<.0001) and BMI from 52.25+/-12.61kg/m(2) Pre-Op to 38.32+/-9.66 Post-Op (p<.0001). Patients demonstrated a statistically significant mean 44% decrease in axial back pain on the VAS scale (p=.006; 5.2+/-3.35 Pre-Op, to 2.9+/-3.1 Post-Op). Analysis of the SF-36 major components revealed that patients experienced significant increases in mean physical health by 58% (p<.0001; 44.5+/-20.09 to 70.24+/-26.84) and in median mental health by 6% (p=.03; 70+/-7.14 to 73.39+/-11.78). Patients also showed statistically significant 24% decrease in Post-Op ODI score for physical disability (p=.05) from 26.75+/-16.56 Pre-Op to 20.35+/-18.71 Post-Op (p=.05).
This study suggests that the substantial weight reduction after bariatric surgery may be associated with moderate reductions in preexisting back pain at early-follow-up. This effect did not appear to be the result only of an overall improvement in well-being associated with weight loss. However, larger randomized controlled clinical studies with longer-term follow-up are needed to definitively determine a causal relationship.
发达国家肥胖症的患病率已达到惊人的水平,自1980年以来美国的肥胖率翻了一番。尽管经常建议患有慢性腰痛的肥胖患者减肥,但这些病症之间的关联仍未得到证实。
本研究前瞻性地评估了因病态肥胖接受减肥手术后体重减轻,慢性轴性腰痛症状在临床上报告的变化。
前瞻性纵向研究。
连续58例患有病态肥胖和慢性轴性腰痛的患者在6个月内接受了减肥手术。如果患者体重比理想体重高50%至100%或体重指数(BMI)大于40,则被视为病态肥胖。
轴性腰痛视觉模拟量表(VAS)、简明健康调查问卷(SF-36)和Oswestry功能障碍指数(ODI)
接受减肥手术的患者在术前和术后12个月使用经过验证的轴性背痛和残疾临床测量方法(VAS、SF-36和ODI)进行评估。减肥手术参数包括人口统计学数据、体重和BMI。统计分析包括配对t检验和多元回归技术。
最初的58例患者中,38例(65%)在12个月时完成了术前(Pre-Op)和术后(Post-Op)问卷。这38名受试者包括30名女性和8名男性,年龄范围为20至68岁(平均48.4±10.1)。总体而言,这些患者的平均体重从术前的144.52±41.21kg降至术后的105.59±29.24kg(p<0.0001),BMI从术前的52.25±12.61kg/m²降至术后的38.32±9.66(p<0.0001)。患者在VAS量表上的轴性背痛平均下降了44%,具有统计学意义(p = 0.006;术前5.2±3.35,术后2.9±3.1)。对SF-36主要成分的分析显示,患者的平均身体健康状况显著提高了58%(p<0.0001;44.5±20.09至70.24±26.84),中位数心理健康状况提高了6%(p = 0.03;70±7.14至73.39±11.78)。患者术后ODI身体残疾评分也显著下降了24%(p = 0.05),从术前的26.75±16.56降至术后的20.35±18.71(p = 0.05)。
本研究表明,减肥手术后体重显著减轻可能与早期随访中原有背痛的适度减轻有关。这种效果似乎不仅仅是与体重减轻相关的整体幸福感改善的结果。然而,需要更大规模的随机对照临床研究和更长时间的随访来明确确定因果关系。