Imperatori Claudio, Farina Benedetto, Todini Federico, Di Blasi Chiara, Mazzucchi Edoardo, Brunetti Valerio, Della Marca Giacomo
1 Department of Human Sciences, European University of Rome, Rome, Italy.
2 Sleep Disorders Unit, Institute of Neurology, Catholic University, Rome, Italy.
Clin EEG Neurosci. 2019 May;50(3):188-195. doi: 10.1177/1550059418780780. Epub 2018 Jun 7.
Transient global amnesia (TGA) is a clinical syndrome characterized by retrograde and anterograde amnesia without other neurological deficits. Although electroencephalography (EEG) methods are commonly used in both clinical and research setting with TGA patients, few studies have investigated neurophysiological pattern in TGA using quantitative EEG (qEEG). The main aim of the present study was to extend these previous findings by exploring EEG power spectra differences between patients with acute TGA and healthy controls using the exact low-resolution brain electromagnetic tomography software (eLORETA). EEG was recorded during 5 minutes of resting state. Sixteen patients (mean age: 66.81 ± 7.94 years) during acute TGA and 16 healthy subjects were enrolled. All patients showed hippocampal or parahippocampal signal abnormalities in diffusion-weighted magnetic resonance imaging performed from 2 to 5 days after the onset of TGA. Compared with healthy controls, TGA patients showed a decrease of theta power localized in the temporal lobe (Brodmann areas, BAs 21-22-38) and frontal lobe (BAs 8-9-44-45). A decrease of EEG beta power in the bilateral precuneus (BA 7) and in the bilateral postcentral gyrus (BAs 3-4-5) was also observed in TGA individuals. Taken together, our results could reflect the neurophysiological substrate of the severe impairment of both episodic memory and autobiographical memory which affect TGA patients during the acute phase.
短暂性全面性遗忘症（TGA）是一种临床综合征，其特征为逆行性和顺行性遗忘，且无其他神经功能缺损。尽管脑电图（EEG）方法在TGA患者的临床和研究中都常用，但很少有研究使用定量脑电图（qEEG）来研究TGA的神经生理模式。本研究的主要目的是通过使用精确低分辨率脑电磁断层扫描软件（eLORETA）探索急性TGA患者与健康对照者之间的EEG功率谱差异，以扩展先前的这些发现。在静息状态下记录5分钟的EEG。纳入了16例急性TGA患者（平均年龄：66.81±7.94岁）和16名健康受试者。所有患者在TGA发作后2至5天进行的扩散加权磁共振成像中均显示海马或海马旁信号异常。与健康对照者相比，TGA患者颞叶（Brodmann区，BA 21 - 22 - 38）和额叶（BA 8 - 9 - 44 - 45）的θ波功率降低。在TGA个体中还观察到双侧楔前叶（BA 7）和双侧中央后回（BA 3 - 4 - 5）的EEGβ波功率降低。综上所述，我们的结果可能反映了急性期影响TGA患者的情景记忆和自传体记忆严重受损的神经生理基础。
