Dana M, Gerodolle M, Koskas Y, Misset J L, Raverdy P, Coscas Y, Miot C, Rougerie J
Presse Med. 1985 May 25;14(21):1173-6.
This retrospective study concerns 55 adult patients with supratentorial glioblastoma. The tumours were treated by complete or partial surgical excision whenever possible (31 cases), radiotherapy (22 cases) in doses of 60 Gy over 6 to 7 weeks (40 Gy with telecobalt and 20 Gy with superimposed electrons) and multiple chemotherapy (10 cases) with VM26 and CCNU or BCNU. Although the number of patients in some categories was too small for statistical evaluation, the results obtained were in agreement with those found in the literature and indicative of what can be expected. In patients with inoperable tumours the mean survival was increased from 2 to 8 months by radiotherapy or chemotherapy given separately, and from 2 to 9 or 10 months only when these two methods were combined. The mean survival of patients with partial tumoral excision was 2.5 months extended to 10 months after post-operative radiotherapy; one patient in this group who received both radiotherapy and chemotherapy is still alive after more than 5 years. In patients with macroscopically satisfactory excision, the 12 months good quality survival obtained by surgery was apparently prolonged to 22 months with radiotherapy; 3 of these patients who had both radiotherapy and chemotherapy after surgery are alive and in good condition after 15, 16 and 28 months respectively.
这项回顾性研究涉及55例幕上胶质母细胞瘤成年患者。只要有可能，肿瘤均采用全部或部分手术切除治疗（31例），放疗（22例），剂量为60 Gy，分6至7周进行（40 Gy采用远距离钴治疗，20 Gy采用叠加电子线治疗），以及采用VM26和CCNU或BCNU进行多次化疗（10例）。尽管某些类别中的患者数量过少，无法进行统计学评估，但所获得的结果与文献中的结果一致，并表明了预期情况。对于无法手术切除的肿瘤患者，单独进行放疗或化疗可使平均生存期从2个月延长至8个月，而只有当这两种方法联合使用时，平均生存期才从2个月延长至9或10个月。部分肿瘤切除患者的平均生存期为2.5个月，术后放疗后延长至10个月；该组中有1例接受了放疗和化疗的患者在5年多后仍然存活。对于肉眼切除效果满意的患者，手术获得的12个月良好生存质量显然通过放疗延长至22个月；其中3例术后接受了放疗和化疗的患者分别在15、16和28个月后仍存活且状况良好。
