Hospital Emergency Department of the Pediatric, University Hospital in Bialystok, Bialystok, Poland.
Department of Pediatrics and Nephrology, Medical University of Bialystok, Bialystok, Poland.
Curr Pharm Des. 2018;24(30):3551-3557. doi: 10.2174/1381612824666180607124531.
The emerging evidence has recently shown an evident dependence between recently identified salusin peptides and atherosclerosis, and their important roles as endogenous modulators of atherogenesis. It was reported that the development of atherosclerosis could also be affected by endogenous salusin- β overproduction in vascular lesions.
MATERIALS/METHODS: This prospective cohort study was conducted in two groups of children: HT - 58 patients with essential hypertension (HT); R - 30 participants with white-coat HT (R). We analysed the relationship between serum salusin- α and salusin- β levels and ADMA, SDMA and hs- CRP in children and adolescents with essential hypertension.
Serum level of salusin- ɑ in each sample was under the sensitivity of method. Serum level of salusin-β was statistically significantly higher in hypertension group when compared to the reference group (p<0.05) and correlated positively with serum hs-CRP [rho=0.47; p<0.01] and asymmetric dimethylarginine (ADMA) [rho=0.32; p<0.05]. There was no significant association between salusin-β and symmetric dimethylarginine (SDMA) [rho=0.27; p>0.05].
This preliminary study showed that the concentration of salusin-β is associated with circulating level of hs-CRP and ADMA in teenagers with hypertension. Further studies are needed to find out if salusin-β levels may indicate for endothelial dysfunction and form the basis for the development of new therapeutic agent.
最近的证据表明，新近发现的 salusin 肽与动脉粥样硬化之间存在明显的依赖性，它们作为动脉粥样形成的内源性调节剂具有重要作用。据报道，血管病变中内源性 salusin-β的过度产生也会影响动脉粥样硬化的发展。
材料/方法：本前瞻性队列研究在两组儿童中进行：HT-58 例原发性高血压（HT）患儿；R-30 例白大衣高血压（R）患儿。我们分析了原发性高血压儿童和青少年血清 salusin-α和 salusin-β水平与 ADMA、SDMA 和 hs-CRP 之间的关系。
每个样本中 salusin-ɑ 的血清水平均低于方法的灵敏度。与对照组相比，高血压组的血清 salusin-β水平统计学上显著升高（p<0.05），与血清 hs-CRP 呈正相关[rho=0.47;p<0.01]和不对称二甲基精氨酸（ADMA）[rho=0.32;p<0.05]。salusin-β与对称二甲基精氨酸（SDMA）[rho=0.27;p>0.05]无显著相关性。
本初步研究表明，salusin-β的浓度与青少年高血压患者循环 hs-CRP 和 ADMA 的水平有关。需要进一步研究以确定 salusin-β水平是否可以指示内皮功能障碍，并为新的治疗药物的开发奠定基础。
