Division of Medical Oncology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey.
Division of Medical Oncology, Department of Internal Medicine, Marmara University School of Medicine, Istanbul, Turkey.
Curr Probl Cancer. 2019 Aug;43(4):308-311. doi: 10.1016/j.currproblcancer.2018.04.003. Epub 2018 May 9.
Primary squamous cell carcinoma (SCC) of the breast is a metaplastic carcinoma subtype which includes fibromatosis-like and sarcomatoid features. This is a very aggressive tumor with poor prognosis. Other sites of primary SCC should be ruled out first to classify these tumors as primary SCC of the breast. Here we present a case of locally advanced primary SCC of the breast.
A 72 years old woman presented with a right axillary lump. Trucut biopsy was performed, it showed squamous cell carcinoma. Estrogen receptor had poor immunoreactivity, negative for both progesteron receptor and HER 2 in immunohistochemistry staining. PETCT imaging were conducted to showing only 6 × 6.5 cm mass in right breast adjacent to axilla, multiple lymphadenomegaly in right axillary. We planned neoadjuvant chemotherapy consisting of weekly paclitaxel followed by epirubicin and cyclophosphamide combination. Postoperative pathology revealed wide necrosis, no viable tumor cell. We started adjuvant anastrozole treatment of 1 mg/day. No evidence of disease was detected after 1 year follow up.
Primary squamous cell carcinoma of the breast is a very rare disease with no standard treatment approach. Our case achieved pathologic complete response after neoadjuvant chemotherapy.
原发性乳腺鳞状细胞癌（SCC）是一种化生癌亚型，包括纤维瘤样和肉瘤样特征。这是一种非常具有侵袭性的肿瘤，预后不良。应首先排除其他部位的原发性 SCC，将这些肿瘤归类为原发性乳腺 SCC。在此，我们报告一例局部晚期原发性乳腺 SCC。
一名 72 岁女性因右侧腋窝肿块就诊。进行了 Trucut 活检，显示为鳞状细胞癌。雌激素受体免疫反应不佳，免疫组织化学染色孕激素受体和 HER 2 均为阴性。进行了 PETCT 成像检查，仅显示右侧乳腺紧邻腋窝处有 6×6.5cm 的肿块，右侧腋窝有多个淋巴结肿大。我们计划进行新辅助化疗，包括每周紫杉醇联合表柔比星和环磷酰胺。术后病理显示广泛坏死，无存活肿瘤细胞。我们开始每天 1 毫克阿那曲唑辅助治疗。随访 1 年后未发现疾病迹象。
原发性乳腺 SCC 是一种非常罕见的疾病，尚无标准的治疗方法。我们的病例在新辅助化疗后达到了病理完全缓解。
