Araki Misato, Matsui Koshi, Takagi Kohji, Kanaya Emi, Sekine Shinichi, Nagasawa Shiho, Watanabe Toru, Miwa Takeshi, Hirano Katsuhisa, Igarashi Takamichi, Tanaka Haruyoshi, Shibuya Kazuto, Hashimoto Isaya, Hojo Shozo, Yoshioka Isaku, Okumura Tomoyuki, Hirabayashi Kenichi, Fujii Tsutomu
Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, 2630, Sugitani, Toyama, 930-0194, Japan.
Department of Diagnostic Pathology, Faculty of Medicine, Academic Assembly, University of Toyama, 2630, Sugitani, Toyama, 930-0194, Japan.
Surg Case Rep. 2023 Aug 2;9(1):137. doi: 10.1186/s40792-023-01719-3.
Squamous cell carcinoma (SCC) of the breast is a rare form of breast cancer, accounting for approximately 0.1% of all breast cancers. It is known for its rapid tumor growth and poor prognosis with no established treatment.
A 56-year-old woman was diagnosed with breast SCC with axillary, supraclavicular and internal thoracic lymph node metastases. She received neoadjuvant chemotherapy (NAC) with dose-dense doxorubicin and cyclophosphamide (AC) followed by dose-dense paclitaxel (PTX). This treatment resulted in a pathological complete response (pCR) after breast-conserving surgery. The patient was then treated with radiotherapy. She remained free of recurrence for three years postoperatively.
We report a rare case of breast SCC treated with preoperative dose-dense chemotherapy, resulting in pCR and allowing breast-conserving surgery.
乳腺鳞状细胞癌（SCC）是一种罕见的乳腺癌形式，约占所有乳腺癌的0.1%。它以肿瘤生长迅速和预后差而闻名，且尚无既定的治疗方法。
一名56岁女性被诊断为乳腺SCC伴腋窝、锁骨上和胸廓内淋巴结转移。她接受了新辅助化疗（NAC），采用剂量密集型阿霉素和环磷酰胺（AC），随后是剂量密集型紫杉醇（PTX）。这种治疗在保乳手术后导致了病理完全缓解（pCR）。患者随后接受了放疗。术后三年她一直无复发。
我们报告了一例罕见的乳腺SCC病例，采用术前剂量密集化疗进行治疗，导致pCR并允许进行保乳手术。
